PMID:23066081

Citation	Dandekar, AA, Chugani, S and Greenberg, EP (2012) Bacterial quorum sensing and metabolic incentives to cooperate. Science 338:264-6
Abstract	The opportunistic pathogen Pseudomonas aeruginosa uses a cell-cell communication system termed "quorum sensing" to control production of public goods, extracellular products that can be used by any community member. Not all individuals respond to quorum-sensing signals and synthesize public goods. Such social cheaters enjoy the benefits of the products secreted by cooperators. There are some P. aeruginosa cellular enzymes controlled by quorum sensing, and we show that quorum sensing-controlled expression of such private goods can put a metabolic constraint on social cheating and prevent a tragedy of the commons. Metabolic constraint of social cheating provides an explanation for private-goods regulation by a cooperative system and has general implications for population biology, infection control, and stabilization of quorum-sensing circuits in synthetic biology.
Links	PubMed PMC3587168 Online version:10.1126/science.1227289
Keywords	Acyl-Butyrolactones/metabolism; Adenosine/metabolism; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Caseins/metabolism; Culture Media/metabolism; Microarray Analysis; Mutation; Pseudomonas aeruginosa/genetics; Pseudomonas aeruginosa/growth & development; Pseudomonas aeruginosa/metabolism; Quorum Sensing/genetics; Quorum Sensing/physiology; Signal Transduction; Social Behavior; Trans-Activators/genetics; Trans-Activators/metabolism
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
PSEAE:LASR		GO:0003700: sequence-specific DNA binding transcription factor activity	ECO:0000315:		F		Figure 1.section 3 shows the mutant strain in the Lux R protein and what happens in the presence of adenosine.	complete CACAO 8650

References

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