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PMID:22984479
| Citation |
Baek, KH, Lee, H, Yang, S, Lim, SB, Lee, W, Lee, JE, Lim, JJ, Jun, K, Lee, DR and Chung, Y (2012) Embryonic demise caused by targeted disruption of a cysteine protease dub-2. PLoS ONE 7:e44223 |
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| Abstract |
A plethora of biological metabolisms are regulated by the mechanisms of ubiquitination, wherein this process is balanced with the action of deubiquitination system. Dub-2 is an IL-2-inducible, immediate-early gene that encodes a deubiquitinating enzyme with growth regulatory activity. DUB-2 presumably removes ubiquitin from ubiquitin-conjugated target proteins regulating ubiquitin-mediated proteolysis, but its specific target proteins are unknown yet. |
| Links |
PubMed PMC3440420 Online version:10.1371/journal.pone.0044223 |
| Keywords |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0043009: chordate embryonic development |
ECO:0000315: |
P |
Table 1 & Figure 4 |
complete | ||||
|
involved_in |
GO:0043009: chordate embryonic development |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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