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Rahimi, N, Rezazadeh, K, Mahoney, JE, Hartsough, E and Meyer, RD (2012) Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis. Mol. Biol. Cell 23:1646-56


Angiogenesis-the growth of new blood vessels from preexisting vessels-is an important physiological process and is considered to play a key role in tumor growth and metastasis. We identified the immunoglobulin-containing and proline-rich receptor-1 (IGPR-1, also called TMIGD2) gene as a novel cell adhesion receptor that is expressed in various human organs and tissues, mainly in cells with epithelium and endothelium origins. IGPR-1 regulates cellular morphology, homophilic cell aggregation, and cell-cell interaction. IGPR-1 activity also modulates actin stress fiber formation and focal adhesion and reduces cell migration. Silencing of expression of IGPR-1 by small interfering RNA (siRNA) and by ectopic overexpression in endothelial cells showed that IGPR-1 regulates capillary tube formation in vitro, and B16F melanoma cells engineered to express IGPR-1 displayed extensive angiogenesis in the mouse Matrigel angiogenesis model. Moreover, IGPR-1, through its proline-rich cytoplasmic domain, associates with multiple Src homology 3 (SH3)-containing signaling proteins, including SH3 protein interacting with Nck (SPIN90/WISH), bullous pemphigoid antigen-1, and calcium channel β2. Silencing of expression of SPIN90/WISH by siRNA in endothelial cells showed that SPIN90/WISH is required for capillary tube formation. These features of IGPR-1 suggest that IGPR-1 is a novel receptor that plays an important role in cell-cell interaction, cell migration, and angiogenesis.


PubMed PMC3338432 Online version:10.1091/mbc.E11-11-0934


Adaptor Proteins, Signal Transducing/metabolism; Amino Acid Sequence; Animals; Cell Adhesion/physiology; Cell Adhesion Molecules/chemistry; Cell Adhesion Molecules/genetics; Cell Adhesion Molecules/metabolism; Cell Movement/physiology; Cells, Cultured; Endothelial Cells/cytology; Endothelial Cells/metabolism; Humans; Melanoma, Experimental/blood supply; Melanoma, Experimental/genetics; Melanoma, Experimental/metabolism; Mice; Molecular Sequence Data; Muscle Proteins/metabolism; Neovascularization, Physiologic/physiology; Receptors, Cell Surface/chemistry; Receptors, Cell Surface/genetics; Receptors, Cell Surface/metabolism; Tissue Distribution



Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status


GO:0045766: positive regulation of angiogenesis



Figure 3- "IGPR-1 activity regulates angiogenesis in vivo and in vitro"

CACAO 6376



GO:0045766: positive regulation of angiogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion


Seeded From UniProt


See also


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