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PMID:22157330
| Citation |
Peng, D, Belkhiri, A, Hu, T, Chaturvedi, R, Asim, M, Wilson, KT, Zaika, A and El-Rifai, W (2012) Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells. Gut 61:1250-60 |
|---|---|
| Abstract |
Exposure of the oesophageal mucosa to gastric acid and bile acids leads to the accumulation of reactive oxygen species (ROS), a known risk factor for Barrett's oesophagus and progression to oesophageal adenocarcinoma (OAC). This study investigated the functions of glutathione peroxidase 7 (GPX7), frequently silenced in OAC, and its capacity in regulating ROS and its associated oxidative DNA damage. |
| Links |
PubMed PMC3419307 Online version:10.1136/gutjnl-2011-301078 |
| Keywords |
Adenocarcinoma/enzymology; Adenocarcinoma/physiopathology; Barrett Esophagus/enzymology; Barrett Esophagus/physiopathology; Bile Acids and Salts/adverse effects; Blotting, Western; Cell Line; DNA Damage/physiology; Disease Progression; Epithelial Cells/enzymology; Esophageal Neoplasms/enzymology; Esophageal Neoplasms/physiopathology; Esophagus/cytology; Esophagus/enzymology; Esophagus/pathology; Flow Cytometry; Gene Expression Regulation; Glutathione Peroxidase/genetics; Glutathione Peroxidase/metabolism; Glutathione Peroxidase/physiology; Humans; Hydrogen Peroxide/metabolism; Oxidative Stress/physiology; Reactive Oxygen Species/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0004096: catalase activity |
ECO:0000314: |
F |
Figure 1B shows an inverse relationship between levels of GPX7 and H202 and its oxidative neutralizing ability. |
complete | ||||
| GO:0055114: oxidation-reduction process |
ECO:0000314: |
P |
Figure 3A shows how GPX7 decreases levels of H202 in epithelial cells exposed to pH 4 bile acids. |
complete | ||||
|
enables |
GO:0004096: catalase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
Notes
See also
References
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