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HUMAN:GPX7
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | GPX7 (synonyms: GPX6) | |
| Protein Name(s) | Glutathione peroxidase 7
GPx-7 GSHPx-7 CL683 | |
| External Links | ||
| UniProt | Q96SL4 | |
| EMBL | AF320068 AY358402 AK027683 DQ096732 AL356976 BC032788 AF091092 | |
| CCDS | CCDS569.1 | |
| RefSeq | NP_056511.2 | |
| UniGene | Hs.43728 | |
| PDB | 2P31 | |
| PDBsum | 2P31 | |
| ProteinModelPortal | Q96SL4 | |
| SMR | Q96SL4 | |
| BioGrid | 109139 | |
| IntAct | Q96SL4 | |
| MINT | MINT-1466561 | |
| STRING | 9606.ENSP00000354677 | |
| DrugBank | DB00143 | |
| PeroxiBase | 3606 | |
| DMDM | 33516901 | |
| MaxQB | Q96SL4 | |
| PaxDb | Q96SL4 | |
| PRIDE | Q96SL4 | |
| DNASU | 2882 | |
| Ensembl | ENST00000361314 | |
| GeneID | 2882 | |
| KEGG | hsa:2882 | |
| UCSC | uc001cue.3 | |
| CTD | 2882 | |
| GeneCards | GC01P053068 | |
| HGNC | HGNC:4559 | |
| HPA | HPA025829 | |
| MIM | 614266 | |
| neXtProt | NX_Q96SL4 | |
| PharmGKB | PA28955 | |
| eggNOG | COG0386 | |
| GeneTree | ENSGT00760000119230 | |
| HOGENOM | HOG000277054 | |
| HOVERGEN | HBG004333 | |
| InParanoid | Q96SL4 | |
| KO | K00432 | |
| OMA | EPDWNFW | |
| OrthoDB | EOG757CZF | |
| PhylomeDB | Q96SL4 | |
| TreeFam | TF331942 | |
| Reactome | REACT_172715 | |
| ChiTaRS | GPX7 | |
| EvolutionaryTrace | Q96SL4 | |
| GeneWiki | GPX7 | |
| GenomeRNAi | 2882 | |
| NextBio | 11381 | |
| PRO | PR:Q96SL4 | |
| Proteomes | UP000005640 | |
| Bgee | Q96SL4 | |
| CleanEx | HS_GPX6 HS_GPX7 | |
| Genevestigator | Q96SL4 | |
| GO | GO:0005783 GO:0005788 GO:0005576 GO:0004602 GO:0004601 GO:0006979 | |
| Gene3D | 3.40.30.10 | |
| InterPro | IPR013376 IPR000889 IPR029759 IPR029760 IPR012336 | |
| PANTHER | PTHR11592 | |
| Pfam | PF00255 | |
| PIRSF | PIRSF000303 | |
| PRINTS | PR01011 | |
| SUPFAM | SSF52833 | |
| TIGRFAMs | TIGR02540 | |
| PROSITE | PS00460 PS00763 PS51355 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0004096 |
catalase activity |
ECO:0000314 |
F |
Figure 1B shows an inverse relationship between levels of GPX7 and H202 and its oxidative neutralizing ability. |
complete | |||||
| GO:0055114 |
oxidation-reduction process |
ECO:0000314 |
P |
Figure 3A shows how GPX7 decreases levels of H202 in epithelial cells exposed to pH 4 bile acids. |
complete | |||||
|
enables |
GO:0004096 |
catalase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004601 |
peroxidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10129 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004601 |
peroxidase activity |
ECO:0000269 |
experimental evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0098869 |
cellular oxidant detoxification |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004602 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0098869 |
cellular oxidant detoxification |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004601 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0098869 |
cellular oxidant detoxification |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004096 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0098869 |
cellular oxidant detoxification |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004601 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0098869 |
cellular oxidant detoxification |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004601 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0098869 |
cellular oxidant detoxification |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004602 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004602 |
glutathione peroxidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006979 |
response to oxidative stress |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004602 |
glutathione peroxidase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034599 |
cellular response to oxidative stress |
Reactome:R-HSA-3299685 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005788 |
endoplasmic reticulum lumen |
Reactome:R-HSA-3341296 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004601 |
peroxidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Peng, D et al. (2012) Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells. Gut 61 1250-60 PubMed GONUTS page
- ↑ 2.0 2.1 Nguyen, VD et al. (2011) Two endoplasmic reticulum PDI peroxidases increase the efficiency of the use of peroxide during disulfide bond formation. J. Mol. Biol. 406 503-15 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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