PMID:22069759

Citation	Gage, E, Hernandez, MO, O'Hara, JM, McCarthy, EA and Mantis, NJ (2011) Role of the Mannose Receptor (CD206) in Innate Immunity to Ricin Toxin. Toxins (Basel) 3:1131-45
Abstract	The entry of ricin toxin into macrophages and certain other cell types in the spleen and liver results in toxin-induced inflammation, tissue damage and organ failure. It has been proposed that uptake of ricin into macrophages is facilitated by the mannose receptor (MR; CD206), a C-type lectin known to recognize the oligosaccharide side chains on ricin's A (RTA) and B (RTB) subunits. In this study, we confirmed that the MR does indeed promote ricin binding, uptake and killing of monocytes in vitro. To assess the role of MR in the pathogenesis of ricin in vivo, MR knockout (MR(-/-)) mice were challenged with the equivalent of 2.5× or 5× LD(50) of ricin by intraperitoneal injection. We found that MR(-/-) mice were significantly more susceptible to toxin-induced death than their age-matched, wild-type control counterparts. These data are consistent with a role for the MR in scavenging and degradation of ricin, not facilitating its uptake and toxicity in vivo.
Links	PubMed PMC3202876 Online version:10.3390/toxins3091131
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
RICCO:RICI		GO:0031640: killing of cells of other organism	ECO:0000314:		P		Ricin toxin binds to the ribosome thereby blocks protein synthesis and cause cell death (Apoptosis). Figure 1 shows a drastic decrease in cell viability with increasing concentration of Ricin.	complete CACAO 3764
RICCO:RICI	involved_in	GO:0031640: killing of cells of other organism	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete

References

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