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PMID:22046243
| Citation |
Cipriani, S, Mencarelli, A, Chini, MG, Distrutti, E, Renga, B, Bifulco, G, Baldelli, F, Donini, A and Fiorucci, S (2011) The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis. PLoS ONE 6:e25637 |
|---|---|
| Abstract |
GP-BAR1, a member G protein coupled receptor superfamily, is a cell surface bile acid-activated receptor highly expressed in the ileum and colon. In monocytes, ligation of GP-BAR1 by secondary bile acids results in a cAMP-dependent attenuation of cytokine generation. |
| Links |
PubMed PMC3203117 Online version:10.1371/journal.pone.0025637 |
| Keywords |
Animals; Cholera Toxin; Ciprofloxacin/pharmacology; Ciprofloxacin/therapeutic use; Colitis/chemically induced; Colitis/drug therapy; Colitis/immunology; Immunity; Intestinal Mucosa/immunology; Intestinal Mucosa/pathology; Ligands; Mice; Mice, Knockout; Permeability; Receptors, G-Protein-Coupled/physiology; Tight Junctions |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:2000810: regulation of tight junction assembly |
ECO:0000315: |
P |
Based on Figure 1 A, B and C |
complete | ||||
|
involved_in |
GO:2000810: regulation of bicellular tight junction assembly |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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