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PMID:2179458
| Citation |
Sharp, PJ, Talbot, RT, Main, GM, Dunn, IC, Fraser, HM and Huskisson, NS (1990) Physiological roles of chicken LHRH-I and -II in the control of gonadotrophin release in the domestic chicken. J. Endocrinol. 124:291-9 |
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| Abstract |
The physiological roles of chicken LHRH-I and -II (cLHRH-I and -II) in the regulation of gonadotrophin release were investigated in the domestic chicken. Measurements of the neuropeptides, using specific radioimmunoassays, in brain sections cut in three planes or in grossly dissected brain areas, showed that cLHRH-II occurs in low amounts throughout the brain whereas cLHRH-I is most abundant in the diencephalon. Within the diencephalon, the largest amount of cLHRH-I occurred in the median eminence of the hypothalamus. The amount of cLHRH-I in the median eminence was higher (P less than 0.05) in laying than in out-of-lay hens. No cLHRH-II was detected in the median eminence in either reproductive state. The amount of cLHRH-I in the hypothalamus was increased (P less than 0.05) in cockerels at the onset of puberty and in somatically immature birds after castration. There were no correlated changes in the amounts of hypothalamic cLHRH-II measured in the same experimental samples. Active immunization of laying hens against cLHRH-I but not against cLHRH-II resulted in the complete regression of the reproductive system and a depression in the concentration of plasma LH. These observations, taken together, suggest that gonadotrophin secretion in the hen is more likely to be directly regulated by cLHRH-I than by cLHRH-II. |
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| Keywords |
Animals; Brain Chemistry; Chickens/physiology; Chorionic Gonadotropin/secretion; Female; Gonadotropin-Releasing Hormone/analogs & derivatives; Gonadotropin-Releasing Hormone/analysis; Gonadotropin-Releasing Hormone/immunology; Gonadotropin-Releasing Hormone/physiology; Hypothalamus/analysis; Immunization; Luteinizing Hormone/blood; Pyrrolidonecarboxylic Acid/analogs & derivatives; Radioimmunoassay/methods |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0000003: reproduction |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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