PMID:21771347

Citation	Yedavalli, VS and Jeang, KT (2011) Matrin 3 is a co-factor for HIV-1 Rev in regulating post-transcriptional viral gene expression. Retrovirology 8:61
Abstract	Post-transcriptional regulation of HIV-1 gene expression is mediated by interactions between viral transcripts and viral/cellular proteins. For HIV-1, post-transcriptional nuclear control allows for the export of intron-containing RNAs which are normally retained in the nucleus. Specific signals on the viral RNAs, such as instability sequences (INS) and Rev responsive element (RRE), are binding sites for viral and cellular factors that serve to regulate RNA-export. The HIV-1 encoded viral Rev protein binds to the RRE found on unspliced and incompletely spliced viral RNAs. Binding by Rev directs the export of these RNAs from the nucleus to the cytoplasm. Previously, Rev co-factors have been found to include cellular factors such as CRM1, DDX3, PIMT and others. In this work, the nuclear matrix protein Matrin 3 is shown to bind Rev/RRE-containing viral RNA. This binding interaction stabilizes unspliced and partially spliced HIV-1 transcripts leading to increased cytoplasmic expression of these viral RNAs.
Links	PubMed PMC3160905 Online version:10.1186/1742-4690-8-61
Keywords	Active Transport, Cell Nucleus; Cell Line; Cell Nucleus/genetics; Cell Nucleus/metabolism; Cytoplasm/genetics; Cytoplasm/metabolism; Gene Expression Regulation, Viral; HIV Infections/genetics; HIV Infections/metabolism; HIV Infections/virology; HIV-1/genetics; HIV-1/metabolism; Humans; Nuclear Matrix-Associated Proteins/genetics; Nuclear Matrix-Associated Proteins/metabolism; Protein Binding; RNA Processing, Post-Transcriptional; RNA, Viral/genetics; RNA, Viral/metabolism; RNA-Binding Proteins/genetics; RNA-Binding Proteins/metabolism; rev Gene Products, Human Immunodeficiency Virus/genetics; rev Gene Products, Human Immunodeficiency Virus/metabolism
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:MATR3		GO:0010608: posttranscriptional regulation of gene expression	ECO:0000314:		P		Figure 3: western blot analysis of anti-HA antibodies shows interaction of Rev and Matrin 3 proteins (lane 8; upper panel)	complete CACAO 8931
HUMAN:MATR3	involved_in	GO:0010608: posttranscriptional regulation of gene expression	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete

References

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