GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:21545744
| Citation |
Dai, L, Huang, Q and Boeke, JD (2011) Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition. BMC Biochem. 12:18 |
|---|---|
| Abstract |
LINE-1s (L1, Long Interspersed Element-1) are the most abundant autonomous non-LTR retrotransposons in the human genome and replicate by reverse transcription of an RNA intermediate. Full-length L1 encodes two open reading frames (ORF1, ORF2) and ORF2 has reverse transcriptase activity. |
| Links |
PubMed PMC3103432 Online version:10.1186/1471-2091-12-18 |
| Keywords |
Amino Acid Sequence; Cell-Free System; Enzyme Assays; Escherichia coli/genetics; HIV-1/enzymology; HIV-2/enzymology; HeLa Cells; Humans; Kinetics; Long Interspersed Nucleotide Elements/genetics; Molecular Sequence Data; RNA-Directed DNA Polymerase/chemistry; RNA-Directed DNA Polymerase/genetics; RNA-Directed DNA Polymerase/metabolism; Reverse Transcriptase Inhibitors/pharmacology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0003964: RNA-directed DNA polymerase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0003964: RNA-directed DNA polymerase activity |
ECO:0000314: |
F |
Figure 2 (blue diamond line) |
complete | ||||
See also
References
See Help:References for how to manage references in GONUTS.
