HV1B1:POL

Species (Taxon ID)	Human immunodeficiency virus type 1 group M subtype B (isolate BH10)(HIV-1). (11678)
Gene Name(s)	gag-pol
Protein Name(s)	Gag-Pol polyprotein Pr160Gag-Pol Matrix protein p17 MA Capsid protein p24 CA Spacer peptide p2 Nucleocapsid protein p7 NC Transframe peptide TF p6-pol p6* Protease PR Retropepsin Reverse transcriptase/ribonuclease H Exoribonuclease H p66 RT p51 RT p15 Integrase IN
External Links
UniProt	P03366
EMBL	M15654 K02083 X01762
PIR	A03965 A03967
PDB	1A9M 1AJV 1AJX 1AXA 1BQM 1BQN 1D4H 1D4I 1D4J 1DLO 1DW6 1EBK 1EBW 1EBY 1EBZ 1EC0 1EC1 1EC2 1EC3 1EET 1G35 1GNM 1GNN 1GNO 1HAR 1HBV 1HEF 1HEG 1HIH 1HMV 1HNI 1HNV 1HOS 1HPS 1HPZ 1HQE 1HQU 1HRH 1HTE 1HTF 1HTG 1HVI 1HVK 1HVP 1HVU 1HYS 1IKV 1IKW 1IKX 1IKY 1J5O 1KJH 1MER 1MES 1MET 1MEU 1N5Y 1N6Q 1NPA 1NPV 1NPW 1QE1 1QMC 1R0A 1RDH 1RTD 1RVL 1RVM 1RVN 1RVO 1RVP 1RVQ 1RVR 1S6P 1S6Q 1S9E 1S9G 1SBG 1SUQ 1SV5 1T03 1T05 1T7K 1TV6 1TVR 1UWB 1W5V 1W5W 1W5X 1W5Y 1YT9 1ZP8 1ZPA 1ZSF 1ZSR 2AQU 2B5J 2B6A 2BAN 2BBB 2BE2 2EXF 2G69 2HB3 2HMI 2HNZ 2HS1 2HS2 2I4D 2I4U 2I4V 2I4W 2I4X 2I5J 2IAJ 2IC3 2IDW 2IEO 2JZW 2L45 2L46 2L4L 2UXZ 2UY0 2VG5 2VG6 2VG7 2X4U 2YKM 2YKN 2ZD1 2ZE2 3AVI 3BGR 3DLK 3GGA 3GGV 3GGX 3HVT 3IG1 3IRX 3IS9 3ISN 3ITH 3JSM 3JYT 3K2P 3K4V 3KLE 3KLF 3KLG 3KLH 3KLI 3NDT 3NU3 3NU4 3NU5 3NU6 3NU9 3NUJ 3NUO 3OK9 3PSU 3QAA 3QLH 3QO9 3TKG 3TKW 3TL9 3TLH 3V4I 3V6D 3V81 3ZPS 3ZPT 3ZPU 4DG1 4G1Q 4G8G 4G8I 4G9D 4G9F 4H4M 4H4O 4I2P 4I2Q 4ICL 4ID5 4IDK 4IFV 4IFY 4IG0 4IG3 4KFB 4KKO 4KO0 4LSL 4LSN 4MFB 4O44 4O4G 4OJR 4PQU 4PUO 4PWD 4Q0B 4QAG 4U8W
PDBsum	1A9M 1AJV 1AJX 1AXA 1BQM 1BQN 1D4H 1D4I 1D4J 1DLO 1DW6 1EBK 1EBW 1EBY 1EBZ 1EC0 1EC1 1EC2 1EC3 1EET 1G35 1GNM 1GNN 1GNO 1HAR 1HBV 1HEF 1HEG 1HIH 1HMV 1HNI 1HNV 1HOS 1HPS 1HPZ 1HQE 1HQU 1HRH 1HTE 1HTF 1HTG 1HVI 1HVK 1HVP 1HVU 1HYS 1IKV 1IKW 1IKX 1IKY 1J5O 1KJH 1MER 1MES 1MET 1MEU 1N5Y 1N6Q 1NPA 1NPV 1NPW 1QE1 1QMC 1R0A 1RDH 1RTD 1RVL 1RVM 1RVN 1RVO 1RVP 1RVQ 1RVR 1S6P 1S6Q 1S9E 1S9G 1SBG 1SUQ 1SV5 1T03 1T05 1T7K 1TV6 1TVR 1UWB 1W5V 1W5W 1W5X 1W5Y 1YT9 1ZP8 1ZPA 1ZSF 1ZSR 2AQU 2B5J 2B6A 2BAN 2BBB 2BE2 2EXF 2G69 2HB3 2HMI 2HNZ 2HS1 2HS2 2I4D 2I4U 2I4V 2I4W 2I4X 2I5J 2IAJ 2IC3 2IDW 2IEO 2JZW 2L45 2L46 2L4L 2UXZ 2UY0 2VG5 2VG6 2VG7 2X4U 2YKM 2YKN 2ZD1 2ZE2 3AVI 3BGR 3DLK 3GGA 3GGV 3GGX 3HVT 3IG1 3IRX 3IS9 3ISN 3ITH 3JSM 3JYT 3K2P 3K4V 3KLE 3KLF 3KLG 3KLH 3KLI 3NDT 3NU3 3NU4 3NU5 3NU6 3NU9 3NUJ 3NUO 3OK9 3PSU 3QAA 3QLH 3QO9 3TKG 3TKW 3TL9 3TLH 3V4I 3V6D 3V81 3ZPS 3ZPT 3ZPU 4DG1 4G1Q 4G8G 4G8I 4G9D 4G9F 4H4M 4H4O 4I2P 4I2Q 4ICL 4ID5 4IDK 4IFV 4IFY 4IG0 4IG3 4KFB 4KKO 4KO0 4LSL 4LSN 4MFB 4O44 4O4G 4OJR 4PQU 4PUO 4PWD 4Q0B 4QAG 4U8W
ProteinModelPortal	P03366
SMR	P03366
IntAct	P03366
MINT	MINT-111903
ChEMBL	CHEMBL5823
SABIO-RK	P03366
EvolutionaryTrace	P03366
Proteomes	UP000007690
GO	GO:0030430 GO:0042025 GO:0020002 GO:0016020 GO:0019013 GO:0004190 GO:0003677 GO:0003887 GO:0004533 GO:0003723 GO:0003964 GO:0004523 GO:0005198 GO:0008270 GO:0015074 GO:0006310 GO:0075713 GO:0039651 GO:0039657 GO:0046718 GO:0075732 GO:0019076
Gene3D	1.10.10.200 1.10.1200.30 1.10.150.90 1.10.375.10 2.30.30.10 2.40.70.10 3.30.420.10 4.10.60.10
InterPro	IPR001969 IPR000721 IPR001037 IPR001584 IPR017856 IPR003308 IPR000071 IPR012344 IPR018061 IPR001995 IPR021109 IPR008916 IPR008919 IPR010999 IPR012337 IPR002156 IPR000477 IPR010659 IPR010661 IPR001878
Pfam	PF00540 PF00607 PF00552 PF02022 PF00075 PF00665 PF00077 PF00078 PF06815 PF06817 PF00098
PRINTS	PR00234
SMART	SM00343
SUPFAM	SSF46919 SSF47353 SSF47836 SSF47943 SSF50122 SSF50630 SSF53098 SSF57756
PROSITE	PS50175 PS00141 PS50994 PS51027 PS50879 PS50878 PS50158 PS50876

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0003964	RNA-directed DNA polymerase activity	PMID:21545744^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004519	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004518	P	Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004523	P	Seeded From UniProt	complete
involved_in	GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004533	P	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001037 InterPro:IPR001878 InterPro:IPR002156 InterPro:IPR036397 InterPro:IPR036862 InterPro:IPR036875	F	Seeded From UniProt	complete
enables	GO:0003964	RNA-directed DNA polymerase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010659 InterPro:IPR010661	F	Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001969 InterPro:IPR001995	F	Seeded From UniProt	complete
enables	GO:0004523	RNA-DNA hybrid ribonuclease activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002156	F	Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000071	F	Seeded From UniProt	complete
involved_in	GO:0006278	RNA-dependent DNA biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010659 InterPro:IPR010661	P	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001969 InterPro:IPR001995	P	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001878 InterPro:IPR003308 InterPro:IPR036875	F	Seeded From UniProt	complete
involved_in	GO:0015074	DNA integration	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001584	P	Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000721 InterPro:IPR008919	P	Seeded From UniProt	complete
enables	GO:0003964	RNA-directed DNA polymerase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.7.49	F	Seeded From UniProt	complete
enables	GO:0004533	exoribonuclease H activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.13.2	F	Seeded From UniProt	complete
enables	GO:0003887	DNA-directed DNA polymerase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.7.7	F	Seeded From UniProt	complete
part_of	GO:0019013	viral nucleocapsid	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0543	C	Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0020002	host cell plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1032 UniProtKB-SubCell:SL-0375	C	Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0064	F	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
involved_in	GO:0039526	modulation by virus of host apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1119	P	Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0233	P	Seeded From UniProt	complete
involved_in	GO:0015074	DNA integration	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0229	P	Seeded From UniProt	complete
involved_in	GO:0039651	induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1073	P	Seeded From UniProt	complete
part_of	GO:0030430	host cell cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1035 UniProtKB-SubCell:SL-0381	C	Seeded From UniProt	complete
involved_in	GO:0075713	establishment of integrated proviral latency	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1179	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0019028	viral capsid	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0167	C	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F	Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P	Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F	Seeded From UniProt	complete
involved_in	GO:0075732	viral penetration into host nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1163	P	Seeded From UniProt	complete
part_of	GO:0019012	virion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0946 UniProtKB-SubCell:SL-0274	C	Seeded From UniProt	complete
enables	GO:0003964	RNA-directed DNA polymerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0695	F	Seeded From UniProt	complete
part_of	GO:0044174	host cell endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1039	C	Seeded From UniProt	complete
involved_in	GO:0044826	viral genome integration into host DNA	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1179	P	Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	P	Seeded From UniProt	complete
part_of	GO:0033644	host cell membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1043	C	Seeded From UniProt	complete
enables	GO:0003887	DNA-directed DNA polymerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0239	F	Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F	Seeded From UniProt	complete
involved_in	GO:0046718	viral entry into host cell	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1160	P	Seeded From UniProt	complete
	GO:0003964	RNA-directed DNA polymerase activity	PMID:21545744^[1]	ECO:0000314			F	Figure 2 (blue diamond line)	complete CACAO 6974
enables	GO:0016779	nucleotidyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0548	F	Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1048 UniProtKB-SubCell:SL-0414	C	Seeded From UniProt	complete
involved_in	GO:0039657	suppression by virus of host gene expression	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1190	P	Seeded From UniProt	complete
part_of	GO:0072494	host multivesicular body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0453	C	Seeded From UniProt	complete
part_of	GO:0055036	virion membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0275	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Dai, L et al. (2011) Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition. BMC Biochem. 12 18 PubMed GONUTS page

[PMID:21545744-1] 1.0 ^1.1 Dai, L et al. (2011) Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition. BMC Biochem. 12 18 PubMed GONUTS page

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HV1B1:POL

Contents

Annotations

Notes

References

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