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PMID:21324212
| Citation |
Bandyopadhyay, K, Parua, PK, Datta, AB and Parrack, P (2011) Studies on Escherichia coli HflKC suggest the presence of an unidentified λ factor that influences the lysis-lysogeny switch. BMC Microbiol. 11:34 |
|---|---|
| Abstract |
The lysis-lysogeny decision in the temperate coliphage λ is influenced by a number of phage proteins (CII and CIII) as well as host factors, viz. Escherichia coli HflB, HflKC and HflD. Prominent among these are the transcription factor CII and HflB, an ATP-dependent protease that degrades CII. Stabilization of CII promotes lysogeny, while its destabilization induces the lytic mode of development. All other factors that influence the lytic/lysogenic decision are known to act by their effects on the stability of CII. Deletion of hflKC has no effect on the stability of CII. However, when λ infects ΔhflKC cells, turbid plaques are produced, indicating stabilization of CII under these conditions. |
| Links |
PubMed PMC3053222 Online version:10.1186/1471-2180-11-34 |
| Keywords |
Bacteriophage lambda/genetics; Bacteriophage lambda/physiology; Escherichia coli/genetics; Escherichia coli/virology; Escherichia coli Proteins/genetics; Gene Deletion; Lysogeny; Peptides/genetics; Transcription Factors/genetics; Viral Plaque Assay; Viral Proteins/genetics |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0006508: proteolysis |
ECO:0000314: |
P |
Knockout phenotypes demonstrated diminished proteolytic activity. |
complete | ||||
See also
References
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