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PMID:21255441
| Citation |
Renault, N, Tobaly-Tapiero, J, Paris, J, Giron, ML, Coiffic, A, Roingeard, P and Saïb, A (2011) A nuclear export signal within the structural Gag protein is required for prototype foamy virus replication. Retrovirology 8:6 |
|---|---|
| Abstract |
The Gag polyproteins play distinct roles during the replication cycle of retroviruses, hijacking many cellular machineries to fulfill them. In the case of the prototype foamy virus (PFV), Gag structural proteins undergo transient nuclear trafficking after their synthesis, returning back to the cytoplasm for capsid assembly and virus egress. The functional role of this nuclear stage as well as the molecular mechanism(s) responsible for Gag nuclear export are not understood. |
| Links |
PubMed PMC3033328 Online version:10.1186/1742-4690-8-6 |
| Keywords |
Cell Nucleus/metabolism; Fatty Acids, Unsaturated/pharmacology; Gene Products, gag/genetics; Gene Products, gag/metabolism; HEK293 Cells; HIV-1/genetics; HeLa Cells; Humans; Mutagenesis, Site-Directed; Nuclear Export Signals; Point Mutation; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Simian foamy virus/physiology; Virus Replication; rev Gene Products, Human Immunodeficiency Virus/chemistry; rev Gene Products, Human Immunodeficiency Virus/metabolism |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005737: cytoplasm |
ECO:0000314: |
C |
Figure1.D. Subcellular localization of GagWT and GagG110V in Hela transfected cells with GagWT or GagG110V and analyzed, 24 h post-transfection, by confocal microscopy following indirect immunofluorescence using rabbit polyclonal anti-PFV. GagWT. |
complete | ||||
| GO:0044444: cytoplasmic part |
ECO:0000314: |
C |
Figure1.D. Subcellular localization of GagWT and GagG110V in Hela transfected cells with GagWT or GagG110V and analyzed, 24 h post-transfection, by confocal microscopy following indirect immunofluorescence using rabbit polyclonal anti-PFV. GagWT. |
complete | ||||
| GO:0033655: host cell cytoplasm part |
ECO:0000314: |
C |
Figure1.D. Subcellular localization of GagWT and GagG110V in Hela transfected cells with GagWT or GagG110V and analyzed, 24 h post-transfection, by confocal microscopy following indirect immunofluorescence using rabbit polyclonal anti-PFV. GagWT. |
complete | ||||
| GO:0000787: cytoplasmic nucleosome |
ECO:0000314: |
C |
Figure1.D. Subcellular localization of GagWT and GagG110V in Hela transfected cells with GagWT or GagG110V and analyzed, 24 h post-transfection, by confocal microscopy following indirect immunofluorescence using rabbit polyclonal anti-PFV. GagWT. |
complete | ||||
| GO:0042025: host cell nucleus |
ECO:0000315: |
C |
Figure1.D. Subcellular localization of GagWT and GagG110V in Hela transfected cells with GagWT or GagG110V and analyzed, 24 h post-transfection, by confocal microscopy following indirect immunofluorescence using rabbit polyclonal anti-PFV. GagWT. The prototype primate foamy virus (PFV), originally designated as human foamy virus (HFV), then as simian foamy virus-chimpanzee (human isolate) [SFVcpz(hu)], is a chimpanzee FV isolated from a human-derived cell culture (Lochelt et al., 1991). |
complete | ||||
| GO:0042025 : host cell cytoplasm |
ECO:0000314: |
C |
Figure1.D. Subcellular localization of GagWT and GagG110V in Hela transfected cells with GagWT or GagG110V and analyzed, 24 h post-transfection, by confocal microscopy following indirect immunofluorescence using rabbit polyclonal anti-PFV. GagWT. |
complete | ||||
Notes
See also
References
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