GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:21050448
| Citation |
Khandelwal, PJ, Dumanis, SB, Feng, LR, Maguire-Zeiss, K, Rebeck, G, Lashuel, HA and Moussa, CE (2010) Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model. Mol Neurodegener 5:47 |
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| Abstract |
α-Synuclein aggregates in Lewy bodies and plays a central role in the pathogenesis of a group of neurodegenerative disorders, known as "Synucleinopathies", including Parkinson's disease. Parkin mutations result in loss of parkin E3-ubiquitin ligase activity and cause autosomal recessive early onset parkinsonism. |
| Links |
PubMed PMC2987994 Online version:10.1186/1750-1326-5-47 |
| Keywords |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
See Help:References for how to manage references in GONUTS.
