GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:20529266

From GONUTS
Jump to: navigation, search
Citation

Hauser, H, Lopez, LA, Yang, SJ, Oldenburg, JE, Exline, CM, Guatelli, JC and Cannon, PM (2010) HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment. Retrovirology 7:51

Abstract

In the absence of the Vpu protein, newly formed HIV-1 particles can remain attached to the surface of human cells due to the action of an interferon-inducible cellular restriction factor, BST-2/tetherin. Tetherin also restricts the release of other enveloped viral particles and is counteracted by a several viral anti-tetherin factors including the HIV-2 Env, SIV Nef and KSHV K5 proteins.

Links

PubMed PMC2890665 Online version:10.1186/1742-4690-7-51

Keywords

Antigens, CD/metabolism; Cell Line; Cell Membrane/chemistry; Endoplasmic Reticulum/chemistry; GPI-Linked Proteins; HIV Envelope Protein gp160/metabolism; HIV-1/pathogenicity; HIV-2/pathogenicity; Host-Pathogen Interactions; Human Immunodeficiency Virus Proteins/metabolism; Humans; Membrane Glycoproteins/metabolism; Microscopy, Confocal; Microscopy, Fluorescence; Protein Binding; Protein Interaction Mapping; Viral Regulatory and Accessory Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HV1BR:VPU

involved_in

GO:0019076: viral release from host cell

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HV1BR:VPU

GO:0019076: viral release from host cell

ECO:0000314:

P

Figure 3

complete
CACAO 3355

Notes

See also

References

See Help:References for how to manage references in GONUTS.