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PMID:20529266
| Citation |
Hauser, H, Lopez, LA, Yang, SJ, Oldenburg, JE, Exline, CM, Guatelli, JC and Cannon, PM (2010) HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment. Retrovirology 7:51 |
|---|---|
| Abstract |
In the absence of the Vpu protein, newly formed HIV-1 particles can remain attached to the surface of human cells due to the action of an interferon-inducible cellular restriction factor, BST-2/tetherin. Tetherin also restricts the release of other enveloped viral particles and is counteracted by a several viral anti-tetherin factors including the HIV-2 Env, SIV Nef and KSHV K5 proteins. |
| Links |
PubMed PMC2890665 Online version:10.1186/1742-4690-7-51 |
| Keywords |
Antigens, CD/metabolism; Cell Line; Cell Membrane/chemistry; Endoplasmic Reticulum/chemistry; GPI-Linked Proteins; HIV Envelope Protein gp160/metabolism; HIV-1/pathogenicity; HIV-2/pathogenicity; Host-Pathogen Interactions; Human Immunodeficiency Virus Proteins/metabolism; Humans; Membrane Glycoproteins/metabolism; Microscopy, Confocal; Microscopy, Fluorescence; Protein Binding; Protein Interaction Mapping; Viral Regulatory and Accessory Proteins/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0019076: viral release from host cell |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0019076: viral release from host cell |
ECO:0000314: |
P |
Figure 3 |
complete | ||||
Notes
See also
References
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