PMID:20161754

Citation	Biswas, S, Reinhard, J, Oakeshott, J, Russell, R, Srinivasan, MV and Claudianos, C (2010) Sensory regulation of neuroligins and neurexin I in the honeybee brain. PLoS ONE 5:e9133
Abstract	Neurexins and neuroligins, which have recently been associated with neurological disorders such as autism in humans, are highly conserved adhesive proteins found on synaptic membranes of neurons. These binding partners produce a trans-synaptic bridge that facilitates maturation and specification of synapses. It is believed that there exists an optimal spatio-temporal code of neurexin and neuroligin interactions that guide synapse formation in the postnatal developing brain. Therefore, we investigated whether neuroligins and neurexin are differentially regulated by sensory input using a behavioural model system with an advanced capacity for sensory processing, learning and memory, the honeybee.
Links	PubMed PMC2817746 Online version:10.1371/journal.pone.0009133
Keywords	Alternative Splicing; Animals; Association Learning/physiology; Bees/genetics; Bees/metabolism; Bees/physiology; Brain/metabolism; Brain/physiology; Cell Adhesion Molecules, Neuronal/genetics; Cell Adhesion Molecules, Neuronal/metabolism; Cell Adhesion Molecules, Neuronal/physiology; Female; Gene Expression Profiling; Insect Proteins/genetics; Insect Proteins/metabolism; Insect Proteins/physiology; Male; Membrane Proteins/genetics; Membrane Proteins/metabolism; Membrane Proteins/physiology; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Nerve Tissue Proteins/physiology; Odors; Olfactory Pathways/physiology; Protein Binding; Reflex/physiology; Reverse Transcriptase Polymerase Chain Reaction; Sensory Receptor Cells/physiology; Smell/physiology; Synapses/physiology
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
APIME:B9VMQ4	involved_in	GO:0008355: olfactory learning	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
APIME:B9VMQ4	involved_in	GO:0007600: sensory perception	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
APIME:B9VMQ4		GO:0007600: sensory perception	ECO:0000315:		P		Bees where isolated and deprived of any sensory stimulus. RNA extraction was taken from the isolated bees and compared against control. It was found that deprived bees had reduced Nlgn1 expression compared to control. Figure 1.	complete CACAO 3148
APIME:B9VMQ4		GO:0008355: olfactory learning	ECO:0000315:		P		Figure 2, associative scent training, long term memory. Brain tissue were analyzed compared to control with no training; there was a up regulation of Nrx1, Nlgn1, Nlgn3.	complete CACAO 3149
APIME:B9VMQ5	involved_in	GO:0008355: olfactory learning	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
APIME:B9VMQ5		GO:0008355: olfactory learning	ECO:0000315:		P		Figure 2, associative scent training, long term memory. Brain tissue were analyzed compared to control bees with no training; there was a up regulation of Nrx1, Nlgn1, Nlgn3.	complete CACAO 3151
APIME:B9VMQ3		GO:0008355: olfactory learning	ECO:0000315:		P		Figure 2, associative scent training, long term memory. Brain tissue were analyzed compared to control with no training; there was a up regulation of Nrx1, Nlgn1, Nlgn3.	complete CACAO 3153
APIME:B9VMQ3	involved_in	GO:0008355: olfactory learning	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete

References

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