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PMID:19767841
| Citation |
Luo, X, Ling, D, Li, T, Wan, C, Zhang, C and Pan, Z (2009) Classical swine fever virus Erns glycoprotein antagonizes induction of interferon-beta by double-stranded RNA. Can. J. Microbiol. 55:698-704 |
|---|---|
| Abstract |
Classical swine fever virus (CSFV) is capable of counteracting innate cellular antiviral responses by inhibiting type I interferon (IFN)-alpha/beta induction. A function associated with CSFV N(pro), with respect to the inhibition of IFN-beta production, has been clearly elucidated. In this study, we explored the role of CSFV E(rns) in IFN-beta induction by exogenous double-stranded (ds) RNA. Synthetic dsRNA (poly (IC)) was used as an exogenous stimulus to trigger IFN-beta induction. CSFV E(rns) inhibited IFN-beta promoter-driven luciferase activity induced by poly (IC) in different cell lines, and the inhibitory effect was dose-dependent. Moreover, E(rns) reduced IFN-beta mRNA synthesis and blocked IFN-alpha/beta production induced by poly (IC), suggesting that this inhibition occurs at the transcriptional level. Furthermore, E(rns) counteracted poly (IC)-mediated IFN-beta induction independent of its ribonuclease activity. In conclusion, CSFV E(rns) antagonizes extracellular dsRNA-mediated IFN-beta expression. These findings contribute to our understanding of the pathogenesis of CSFV. |
| Links |
PubMed Online version:10.1139/w09-013 |
| Keywords |
Animals; Cell Line; Classical Swine Fever/genetics; Classical Swine Fever/immunology; Classical Swine Fever/virology; Classical Swine Fever Virus; Humans; Interferon-beta/genetics; Interferon-beta/immunology; Poly I-C/immunology; Promoter Regions, Genetic; RNA, Double-Stranded/immunology; Swine; Transcriptional Activation; Viral Envelope Proteins/immunology |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0039502: suppression by virus of host type I interferon-mediated signaling pathway |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
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Notes
See also
References
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