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PMID:18932275
| Citation |
Su, K, Chen, F, Yan, WM, Zeng, QL, Xu, L, Xi, D, Pi, B, Luo, XP and Ning, Q (2008) Fibrinogen-like protein 2/fibroleukin prothrombinase contributes to tumor hypercoagulability via IL-2 and IFN-gamma. World J. Gastroenterol. 14:5980-9 |
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| Abstract |
To examine the role of Fibrinogen-like protein 2 (fgl2)/fibroleukin in tumor development. Fgl2 has been reported to play a vital role in the pathogenesis in MHV-3 (mouse hepatitis virus) induced fulminant and severe hepatitis, spontaneous abortion, allo- and xeno- graft rejection by mediating "immune coagulation". |
| Links | |
| Keywords |
Adult; Aged; Animals; Carcinoma, Hepatocellular/metabolism; Carcinoma, Hepatocellular/pathology; Cell Line; Cell Line, Tumor; Disease Models, Animal; Endothelial Cells/metabolism; Endothelial Cells/pathology; Female; Fibrinogen/metabolism; Humans; Interferon-gamma/metabolism; Interleukin-2/metabolism; Leukemia, Monocytic, Acute/metabolism; Leukemia, Monocytic, Acute/pathology; Liver Neoplasms/metabolism; Liver Neoplasms/pathology; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; RNA, Messenger/metabolism; Thrombophilia/metabolism; Thromboplastin/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002836: positive regulation of response to tumor cell |
ECO:0000314: |
P |
table 2- cells displayed increased expression of fgl2 protein in tumor tissues of the patients |
complete | ||||
See also
References
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