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MOUSE:FGL2
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Fgl2 (synonyms: Fiblp) | |
| Protein Name(s) | Fibroleukin
Cytotoxic T-lymphocyte-specific protein Fibrinogen-like protein 2 Prothrombinase | |
| External Links | ||
| UniProt | P12804 | |
| EMBL | M16238 M15761 S78773 BC028893 | |
| CCDS | CCDS19103.1 | |
| PIR | A27447 I56934 | |
| RefSeq | NP_032039.2 | |
| UniGene | Mm.292100 | |
| ProteinModelPortal | P12804 | |
| SMR | P12804 | |
| MEROPS | S67.001 | |
| MaxQB | P12804 | |
| PaxDb | P12804 | |
| PRIDE | P12804 | |
| Ensembl | ENSMUST00000035799 | |
| GeneID | 14190 | |
| KEGG | mmu:14190 | |
| UCSC | uc008wom.2 | |
| CTD | 10875 | |
| MGI | MGI:103266 | |
| eggNOG | NOG297117 | |
| HOGENOM | HOG000252953 | |
| HOVERGEN | HBG105002 | |
| InParanoid | P12804 | |
| OMA | FYVANEF | |
| OrthoDB | EOG7X9G60 | |
| PhylomeDB | P12804 | |
| TreeFam | TF336658 | |
| NextBio | 285406 | |
| PRO | PR:P12804 | |
| Proteomes | UP000000589 | |
| Bgee | P12804 | |
| CleanEx | MM_FGL2 | |
| ExpressionAtlas | P12804 | |
| Genevestigator | P12804 | |
| GO | GO:0070062 GO:0019835 | |
| Gene3D | 3.90.215.10 4.10.530.10 | |
| InterPro | IPR014716 IPR014715 IPR002181 IPR020837 | |
| Pfam | PF00147 | |
| SMART | SM00186 | |
| SUPFAM | SSF56496 | |
| PROSITE | PS00514 PS51406 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
acts_upstream_of_or_within |
GO:0050687 |
negative regulation of defense response to virus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3582343 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0002617 |
negative regulation of macrophage antigen processing and presentation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3582343 |
P |
Seeded From UniProt |
complete | ||
| GO:0002836 |
positive regulation of response to tumor cell |
ECO:0000314 |
P |
table 2- cells displayed increased expression of fgl2 protein in tumor tissues of the patients |
complete | |||||
|
acts_upstream_of_or_within |
GO:0002605 |
negative regulation of dendritic cell antigen processing and presentation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3582343 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0002381 |
immunoglobulin production involved in immunoglobulin mediated immune response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3582343 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0002291 |
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3582343 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008233 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019835 |
cytolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Luft, O et al. (2018) Inhibition of the Fibrinogen-Like Protein 2:FcγRIIB/RIII immunosuppressive pathway enhances antiviral T-cell and B-cell responses leading to clearance of lymphocytic choriomeningitis virus clone 13. Immunology 154 476-489 PubMed GONUTS page
- ↑ Su, K et al. (2008) Fibrinogen-like protein 2/fibroleukin prothrombinase contributes to tumor hypercoagulability via IL-2 and IFN-gamma. World J. Gastroenterol. 14 5980-9 PubMed GONUTS page
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