PMID:18621693

Citation	Arrighi, JF, Godfroy, O, de Billy, F, Saurat, O, Jauneau, A and Gough, C (2008) The RPG gene of Medicago truncatula controls Rhizobium-directed polar growth during infection. Proc. Natl. Acad. Sci. U.S.A. 105:9817-22
Abstract	Rhizobia can infect roots of host legume plants and induce new organs called nodules, in which they fix atmospheric nitrogen. Infection generally starts with root hair curling, then proceeds inside newly formed, intracellular tubular structures called infection threads. A successful symbiotic interaction relies on infection threads advancing rapidly at their tips by polar growth through successive cell layers of the root toward developing nodule primordia. To identify a plant component that controls this tip growth process, we characterized a symbiotic mutant of Medicago truncatula, called rpg for rhizobium-directed polar growth. In this mutant, nitrogen-fixing nodules were rarely formed due to abnormally thick and slowly progressing infection threads. Root hair curling was also abnormal, indicating that the RPG gene fulfils an essential function in the process whereby rhizobia manage to dominate the process of induced tip growth for root hair infection. Map-based cloning of RPG revealed a member of a previously unknown plant-specific gene family encoding putative long coiled-coil proteins we have called RRPs (RPG-related proteins) and characterized by an "RRP domain" specific to this family. RPG expression was strongly associated with rhizobial infection, and the RPG protein showed a nuclear localization, indicating that this symbiotic gene constitutes an important component of symbiotic signaling.
Links	PubMed PMC2474542 Online version:10.1073/pnas.0710273105
Keywords	Base Sequence; Genes, Plant/genetics; Genes, Plant/physiology; Medicago truncatula/genetics; Medicago truncatula/microbiology; Molecular Sequence Data; Mutation; Nuclear Proteins/genetics; Nuclear Proteins/physiology; Plant Proteins/genetics; Plant Proteins/physiology; Plant Roots/growth & development; Plant Roots/microbiology; Rhizobium; Symbiosis
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
MEDTR:B3RH40		GO:0005634: nucleus	ECO:0000314:		C		Figure 3	complete CACAO 8443
MEDTR:B3RH40	part_of	GO:0005634: nucleus	ECO:0000314: direct assay evidence used in manual assertion		C		Seeded From UniProt	complete

References

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