GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:18603306
| Citation |
El Karim, IA, Linden, GJ, Orr, DF and Lundy, FT (2008) Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites. J. Neuroimmunol. 200:11-6 |
|---|---|
| Abstract |
Many neuropeptides are similar in size, amino acid composition and charge to antimicrobial peptides. This study aimed to determine whether the neuropeptides substance P (SP), neurokinin A (NKA), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY) and vasoactive intestinal polypeptide (VIP), displayed antimicrobial activity against Streptococcus mutans, Lactobacillus acidophilus, Enterococcus faecalis, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. SP, NPY, VIP and CGRP displayed variable degrees of antimicrobial activity against all the pathogens tested with the exception of S. aureus. These antimicrobial activities add a further dimension to the immunomodulatory roles for neuropeptides in the inflammatory and immune responses. |
| Links |
PubMed Online version:10.1016/j.jneuroim.2008.05.014 |
| Keywords |
Anti-Infective Agents/pharmacology; Anticoagulants/pharmacology; Bacteria/classification; Bacteria/drug effects; Escherichia coli/drug effects; Escherichia coli/immunology; Gastrointestinal Tract/microbiology; Heparin/pharmacology; Humans; Microbial Sensitivity Tests; Mouth/microbiology; Neuropeptides/pharmacology; Respiratory System/microbiology; Skin/microbiology; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods; Tetrazolium Salts; Thiazoles |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0001878: response to yeast |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019731: antibacterial humoral response |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019732: antifungal humoral response |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045087: innate immune response |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050829: defense response to Gram-negative bacterium |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050830: defense response to Gram-positive bacterium |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061844: antimicrobial humoral immune response mediated by antimicrobial peptide |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
Notes
See also
References
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