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HUMAN:VIP

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) VIP
Protein Name(s) VIP peptides

Intestinal peptide PHV-42 Peptide histidine valine 42 Intestinal peptide PHM-27 Peptide histidine methioninamide 27 Vasoactive intestinal peptide VIP Vasoactive intestinal polypeptide

External Links
UniProt P01282
EMBL L00157
L00154
L00155
L00156
M11553
M11549
M11550
M11551
M11552
M36634
M14623
M14619
M14620
M14621
M14622
M33027
AL133356
AL133356
BC009794
M36610
M36606
M36607
M36608
M36609
M54930
M32162
M31645
CCDS CCDS5240.1
CCDS5241.1
PIR A23296
RefSeq NP_003372.1
NP_919416.1
UniGene Hs.53973
PDB 2RRH
2RRI
PDBsum 2RRH
2RRI
ProteinModelPortal P01282
SMR P01282
BioGrid 113273
IntAct P01282
MINT MINT-1473277
STRING 9606.ENSP00000356213
ChEMBL CHEMBL5737
PhosphoSite P01282
DMDM 138574
PaxDb P01282
PRIDE P01282
DNASU 7432
Ensembl ENST00000367243
ENST00000367244
GeneID 7432
KEGG hsa:7432
UCSC uc003qpe.4
uc003qpf.4
CTD 7432
GeneCards GC06P153164
HGNC HGNC:12693
HPA CAB018649
HPA017324
MIM 192320
neXtProt NX_P01282
PharmGKB PA37312
eggNOG NOG44083
GeneTree ENSGT00530000063592
HOGENOM HOG000253943
HOVERGEN HBG018069
InParanoid P01282
KO K05264
OMA FSHTLAW
OrthoDB EOG7QVM4H
PhylomeDB P01282
TreeFam TF332804
Reactome REACT_19327
EvolutionaryTrace P01282
GeneWiki Vasoactive_intestinal_peptide
GenomeRNAi 7432
NextBio 29108
PRO PR:P01282
Proteomes UP000005640
Bgee P01282
CleanEx HS_VIP
Genevestigator P01282
GO GO:0005576
GO:0043025
GO:0005179
GO:0005184
GO:0007589
GO:0007186
GO:0007611
GO:0043066
GO:0043267
GO:0048662
GO:0010579
GO:0008284
GO:0001938
GO:0060406
GO:0045732
GO:0045909
GO:0032880
GO:0051930
GO:0009966
InterPro IPR000532
IPR015523
PANTHER PTHR11213:SF5
Pfam PF00123
SMART SM00070
PROSITE PS00260

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0035425

autocrine signaling

PMID:28181929[1]

ECO:0000314

P

Figure 1. When treated with VIP, the cornea precut increased N-cadherin levels seen using a Western blot analysis.

Figure 4. There was reduced damage of the cornea precut demonstrated microscopically. VIP treated Cornea precuts showed less damage than their control, indicating that the VIP signaling had up-regulated N-cadherin in a kinase A-dependent manner.

complete
CACAO 12581

enables

GO:0051428

peptide hormone receptor binding

PMID:8390245[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P32241

F

Seeded From UniProt

complete

involved_in

GO:0048255

mRNA stabilization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P45644:PRO_0000011484

P

Seeded From UniProt

complete

involved_in

GO:0070459

prolactin secretion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P45644:PRO_0000011484

P

Seeded From UniProt

complete

involved_in

GO:0045732

positive regulation of protein catabolic process

PMID:9603988[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032880

regulation of protein localization

PMID:9603988[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:9603988[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

PMID:9603988[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0097755

positive regulation of blood vessel diameter

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002598709
RGD:621647

P

Seeded From UniProt

complete

involved_in

GO:0060406

positive regulation of penile erection

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002598709
RGD:621647

P

Seeded From UniProt

complete

involved_in

GO:0051930

regulation of sensory perception of pain

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002598709
RGD:621647

P

Seeded From UniProt

complete

enables

GO:0051428

peptide hormone receptor binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000130195
UniProtKB:P18509

F

Seeded From UniProt

complete

involved_in

GO:0048662

negative regulation of smooth muscle cell proliferation

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002598709
RGD:621647

P

Seeded From UniProt

complete

involved_in

GO:0048242

epinephrine secretion

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002598709
UniProtKB:P48143

P

Seeded From UniProt

complete

involved_in

GO:0045732

positive regulation of protein catabolic process

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98933
PANTHER:PTN002598709
RGD:621647
UniProtKB:P01282
UniProtKB:P01284
UniProtKB:P81401

P

Seeded From UniProt

complete

involved_in

GO:0043267

negative regulation of potassium ion transport

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002598709
RGD:621647

P

Seeded From UniProt

complete

part_of

GO:0043204

perikaryon

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002598709
UniProtKB:P48143

C

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002598709
RGD:621647

P

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002598709
UniProtKB:P48143

C

Seeded From UniProt

complete

involved_in

GO:0032880

regulation of protein localization

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98933
PANTHER:PTN002598709
RGD:621647
UniProtKB:P01282
UniProtKB:P01284
UniProtKB:P81401

P

Seeded From UniProt

complete

involved_in

GO:0032812

positive regulation of epinephrine secretion

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002598709
UniProtKB:P48143

P

Seeded From UniProt

complete

involved_in

GO:0007611

learning or memory

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002598709
RGD:621647

P

Seeded From UniProt

complete

involved_in

GO:0007200

phospholipase C-activating G protein-coupled receptor signaling pathway

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002598709
ZFIN:ZDB-GENE-080204-3

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:105094
MGI:MGI:95709
MGI:MGI:98933
PANTHER:PTN000130195
RGD:2037
RGD:61883
RGD:621647
UniProtKB:P01282
UniProtKB:P01284
UniProtKB:P01286
UniProtKB:P18509
UniProtKB:P41535
UniProtKB:P48143
UniProtKB:P81401
UniProtKB:Q29W19

P

Seeded From UniProt

complete

enables

GO:0005184

neuropeptide hormone activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000130195
RGD:2037
UniProtKB:P18509
UniProtKB:Q29W19

F

Seeded From UniProt

complete

involved_in

GO:0001938

positive regulation of endothelial cell proliferation

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002598709
RGD:621647

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005184

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005184

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000532

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000532

C

Seeded From UniProt

complete

involved_in

GO:0070459

prolactin secretion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P45644:PRO_0000011484

P

Seeded From UniProt

complete

involved_in

GO:0048255

mRNA stabilization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P45644:PRO_0000011484

P

Seeded From UniProt

complete

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:18603306[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:18603306[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050829

defense response to Gram-negative bacterium

PMID:18603306[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

PMID:18603306[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019732

antifungal humoral response

PMID:18603306[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019731

antibacterial humoral response

PMID:18603306[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001878

response to yeast

PMID:18603306[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:8389448[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007589

body fluid secretion

PMID:4035357[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

PMID:10096039[8]
Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

enables

GO:0005184

neuropeptide hormone activity

PMID:10096039[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-744887
Reactome:R-HSA-744886
Reactome:R-HSA-420233
Reactome:R-HSA-379044

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0372

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Koh, SM et al. (2017) Corneal Endothelial Cell Integrity in Precut Human Donor Corneas Enhanced by Autocrine Vasoactive Intestinal Peptide. Cornea 36 476-483 PubMed GONUTS page
  2. ↑ Sreedharan, SP et al. (1993) Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor. Biochem. Biophys. Res. Commun. 193 546-53 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Yajima, Y et al. (1998) VIP induces the translocation and degradation of the alpha subunit of Gs protein in rat pituitary GH4C1 cells. J. Biochem. 123 1024-30 PubMed GONUTS page
  4. ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 4.15 4.16 4.17 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 El Karim, IA et al. (2008) Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites. J. Neuroimmunol. 200 11-6 PubMed GONUTS page
  6. ↑ Moody, TW et al. (1993) A vasoactive intestinal peptide antagonist inhibits non-small cell lung cancer growth. Proc. Natl. Acad. Sci. U.S.A. 90 4345-9 PubMed GONUTS page
  7. ↑ Heinz-Erian, P et al. (1985) Deficient vasoactive intestinal peptide innervation in the sweat glands of cystic fibrosis patients. Science 229 1407-8 PubMed GONUTS page
  8. ↑ 8.0 8.1 Olde, B et al. (1998) Molecular mapping of epitopes involved in ligand activation of the human receptor for the neuropeptide, VIP, based on hybrids with the human secretin receptor. J. Mol. Neurosci. 11 127-34 PubMed GONUTS page
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