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PMID:18250190
| Citation |
Davies, TA, Shang, W, Bush, K and Flamm, RK (2008) Affinity of doripenem and comparators to penicillin-binding proteins in Escherichia coli and Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 52:1510-2 |
|---|---|
| Abstract |
Doripenem, a parenteral carbapenem, exhibited high affinity for penicillin-binding protein 2 (PBP2) and PBP3 in Pseudomonas aeruginosa and PBP2 in Escherichia coli, the primary PBPs whose inhibition leads to cell death. This PBP affinity profile correlates with the broad-spectrum gram-negative activity observed with doripenem. |
| Links |
PubMed PMC2292531 Online version:10.1128/AAC.01529-07 |
| Keywords |
Anti-Bacterial Agents/metabolism; Anti-Bacterial Agents/pharmacology; Bacterial Proteins/metabolism; Carbapenems/metabolism; Carbapenems/pharmacology; Escherichia coli/drug effects; Escherichia coli/metabolism; Escherichia coli Proteins/metabolism; Humans; Inhibitory Concentration 50; Microbial Sensitivity Tests; Penicillin-Binding Proteins/metabolism; Pseudomonas aeruginosa/drug effects; Pseudomonas aeruginosa/metabolism; beta-Lactams/metabolism; beta-Lactams/pharmacology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0008144: drug binding |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042493: response to drug |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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