GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:17664006
| Citation |
Yang, J, Yang, Y, Chen, JM, Liu, WY, Wang, CH and Lin, BC (2007) Effect of oxytocin on acupuncture analgesia in the rat. Neuropeptides 41:285-92 |
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| Abstract |
Oxytocin has been demonstrated to be involved in pain modulation. Acupuncture analgesia is a very useful clinical tool for pain relief, which has over 2500-year history in China. The present study investigated the role of oxytocin in acupuncture analgesia in the rat through oxytocin administration and measurement. Central administration of oxytocin (intraventricular injection or intrathecal injection) enhanced acupuncture analgesia, while central administration of anti-oxytocin serum weakened acupuncture analgesia in a dose-dependent manner. However, intravenous injection of oxytocin or anti-oxytocin serum did not influence acupuncture analgesia. Electrical acupuncture of "Zusanli" (St. 36) reduced oxytocin concentration in the hypothalamic supraoptic nucleus, and elevated oxytocin concentration in the hypothalamic suprachiasmatic nucleus, hypothalamic ventromedial nucleus, thalamic ventral nucleus, periaqueductal gray, raphe magnus nucleus, caudate nucleus, thoracic spinal cord and lumbar spinal cord, but did not alter oxytocin concentration in the hypothalamic paraventricular nucleus, anterior pituitary, posterior pituitary and plasma. The data suggested that oxytocin in central nervous system rather than in peripheral organs is involved in acupuncture analgesia. |
| Links |
PubMed Online version:10.1016/j.npep.2007.05.004 |
| Keywords |
Acupuncture; Analgesia; Animals; Cerebral Ventricles/drug effects; Cerebral Ventricles/physiology; Cerebral Ventricles/physiopathology; Electric Stimulation; Injections, Intraventricular; Injections, Spinal; Male; Oxytocin/administration & dosage; Oxytocin/pharmacology; Pain/prevention & control; Pituitary Gland/drug effects; Pituitary Gland/physiology; Pituitary Gland/physiopathology; Rats; Rats, Sprague-Dawley; Spinal Cord/drug effects; Spinal Cord/physiology; Spinal Cord/physiopathology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0051930: regulation of sensory perception of pain |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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