PMID:17559853

Citation	Bernal, A, Mahía, J and Puerto, A (2007) Oxytocin, water intake, and food sodium availability in male rats. Horm Behav 52:289-96
Abstract	This study examined the effect of subcutaneous administration of the neurohormone oxytocin on water intake of ad lib-fed (with or without sodium availability in the diet) and food-deprived animals. Results of the first experiment showed that oxytocin increased water intake and urine excretion in food-deprived but not in ad lib-fed animals. However, oxytocin treatment did not modify the reduced water "balance" (fluid intake minus urine volume) resulting from food deprivation or the daily food intake (Experiment 1). The dose-dependent polydipsic effect of oxytocin on food-deprived rats was always preceded by an increase in sodium and fluid urine excretion (Experiment 2). Oxytocin also increased the water intake of animals fed ad lib with a low sodium diet (Experiment 3). These results suggest that the effect of oxytocin on water intake is dependent on the presence or absence of sodium in the diet and that the excretion of sodium is the main mechanism of oxytocinergic polydipsia in food-deprived male rats.
Links	PubMed Online version:10.1016/j.yhbeh.2007.05.005
Keywords	Animals; Dose-Response Relationship, Drug; Drinking/drug effects; Drinking/physiology; Food Deprivation/physiology; Injections, Subcutaneous; Kidney Concentrating Ability/physiology; Male; Oxytocin/administration & dosage; Oxytocin/physiology; Rats; Rats, Wistar; Sodium, Dietary/urine; Water-Electrolyte Balance/drug effects; Water-Electrolyte Balance/physiology
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
RAT:NEU1	involved_in	GO:0035815: positive regulation of renal sodium excretion	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete

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