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PMID:17470659
| Citation |
Davies, TA, Page, MG, Shang, W, Andrew, T, Kania, M and Bush, K (2007) Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. Antimicrob. Agents Chemother. 51:2621-4 |
|---|---|
| Abstract |
Ceftobiprole exhibited tight binding to PBP2a in methicillin-resistant Staphylococcus aureus, PBP2x in penicillin-resistant Streptococcus pneumoniae, and PBP3 and other essential penicillin-binding proteins in methicillin-susceptible S. aureus, Escherichia coli, and Pseudomonas aeruginosa. Ceftobiprole also bound well to PBP2 in the latter organisms, contributing to the broad-spectrum antibacterial activity against gram-negative and gram-positive bacteria. |
| Links |
PubMed PMC1913263 Online version:10.1128/AAC.00029-07 |
| Keywords |
Bacterial Proteins/metabolism; Cephalosporins/metabolism; Escherichia coli Proteins/metabolism; Gram-Negative Bacteria/metabolism; Inhibitory Concentration 50; Microbial Sensitivity Tests; Penicillin-Binding Proteins/metabolism; Pseudomonas aeruginosa/chemistry; Pseudomonas aeruginosa/metabolism; Staphylococcus aureus/chemistry; Staphylococcus aureus/metabolism; Streptococcus pneumoniae/chemistry; Streptococcus pneumoniae/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0008144: drug binding |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042493: response to drug |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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