PMID:1653648

Citation	Kuroda, MI, Kernan, MJ, Kreber, R, Ganetzky, B and Baker, BS (1991) The maleless protein associates with the X chromosome to regulate dosage compensation in Drosophila. Cell 66:935-47
Abstract	The maleless (mle) gene is one of four known regulatory loci required for increased transcription (dosage compensation) of X-linked genes in D. melanogaster males. A predicted mle protein (MLE) contains seven short segments that define a superfamily of known and putative RNA and DNA helicases. MLE, while present in the nuclei of both male and female cells, differs in its association with polytene X chromosomes in the two sexes. MLE is associated with hundreds of discrete sites along the length of the X chromosome in males and not in females. The predominant localization of MLE to the X chromosome in males makes it a strong candidate to be a direct regulator of dosage compensation.
Links	PubMed
Keywords	Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Cell Compartmentation; Chromosomal Proteins, Non-Histone; Chromosome Mapping; Cloning, Molecular; DNA Helicases/genetics; DNA Helicases/immunology; DNA Helicases/metabolism; DNA-Binding Proteins; Dosage Compensation, Genetic; Drosophila Proteins; Drosophila melanogaster/genetics; Female; Fluorescent Antibody Technique; Gene Expression Regulation; Genes, Regulator; Insect Hormones/genetics; Insect Hormones/immunology; Insect Hormones/metabolism; Male; Molecular Sequence Data; Nuclear Proteins/genetics; Nuclear Proteins/immunology; Nuclear Proteins/metabolism; RNA, Messenger/genetics; Transcription Factors/genetics; Transcription Factors/immunology; Transcription Factors/metabolism; Transcription, Genetic; X Chromosome
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
DROME:MLE	part_of	GO:0005700: polytene chromosome	ECO:0000314: direct assay evidence used in manual assertion		C		Seeded From UniProt	complete

References

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