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PMID:15765407
| Citation |
Nathan, JD, Romac, J, Peng, RY, Peyton, M, Macdonald, RJ and Liddle, RA (2005) Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice. Gastroenterology 128:717-27 |
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| Abstract |
Endogenous trypsin inhibitors are believed to inhibit protease activity if trypsin becomes inadvertently activated within the acinar cell. However, this action remains unproven, and the role of endogenous pancreatic trypsin inhibitors in acute pancreatitis is unknown. In this study, we tested whether increased levels of pancreatic secretory trypsin inhibitor-I (PSTI-I) in mice could prevent secretagogue-induced pancreatitis. |
| Links | |
| Keywords |
Animals; Ceruletide; Gene Expression; Immunologic Techniques; Intercellular Signaling Peptides and Proteins/genetics; Intercellular Signaling Peptides and Proteins/metabolism; Mice; Mice, Inbred Strains; Mice, Transgenic; Microscopy, Electron; Oligopeptides/metabolism; Pancreas/metabolism; Pancreas/pathology; Pancreatitis/chemically induced; Pancreatitis/metabolism; Pancreatitis/pathology; Rats; Staining and Labeling; Transgenes; Trypsin/metabolism |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005737: cytoplasm |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
Notes
See also
References
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