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RAT:ISK1
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Spink1 | |
| Protein Name(s) | Pancreatic secretory trypsin inhibitor
Cholecystokinin-releasing peptide Monitor peptide PSTI-I Serine protease inhibitor Kazal-type 1 | |
| External Links | ||
| UniProt | P09655 | |
| EMBL | X59696 M22162 M35299 M35300 M27882 D11321 | |
| PIR | S09602 | |
| RefSeq | NP_036806.1 | |
| UniGene | Rn.9767 | |
| ProteinModelPortal | P09655 | |
| STRING | 10116.ENSRNOP00000018110 | |
| MEROPS | I01.011 | |
| PRIDE | P09655 | |
| Ensembl | ENSRNOT00000018110 | |
| GeneID | 24833 | |
| KEGG | rno:24833 | |
| UCSC | RGD:3749 | |
| CTD | 20730 | |
| RGD | 3749 | |
| eggNOG | NOG255629 | |
| GeneTree | ENSGT00530000064228 | |
| HOGENOM | HOG000090244 | |
| HOVERGEN | HBG006182 | |
| InParanoid | P09655 | |
| OMA | CATIFKE | |
| OrthoDB | EOG7BW0M2 | |
| PhylomeDB | P09655 | |
| NextBio | 604564 | |
| Proteomes | UP000002494 | |
| Genevestigator | P09655 | |
| GO | GO:0005615 GO:0004866 GO:0004867 GO:0010951 GO:0045861 | |
| InterPro | IPR002350 | |
| Pfam | PF00050 | |
| SMART | SM00280 | |
| PROSITE | PS00282 PS51465 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004867 |
serine-type endopeptidase inhibitor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900004 |
negative regulation of serine-type endopeptidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090277 |
positive regulation of peptide hormone secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090187 |
positive regulation of pancreatic juice secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071375 |
cellular response to peptide hormone stimulus |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050679 |
positive regulation of epithelial cell proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045471 |
response to ethanol |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031667 |
response to nutrient levels |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004867 |
serine-type endopeptidase inhibitor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010466 |
negative regulation of peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030414 |
peptidase inhibitor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Uda, K et al. (1994) Elevation of circulating monitor peptide/pancreatic secretory trypsin inhibitor-I (PSTI-61) after turpentine-induced inflammation in rats: hepatocytes produce it as an acute phase reactant. J. Surg. Res. 57 563-8 PubMed GONUTS page
- ↑ 2.0 2.1 Graf, R et al. (2003) The bifunctional rat pancreatic secretory trypsin inhibitor/monitor peptide provides protection against premature activation of pancreatic juice. Pancreatology 3 195-206 PubMed GONUTS page
- ↑ 3.0 3.1 Miyasaka, K et al. (1989) Stimulatory effect of monitor peptide and human pancreatic secretory trypsin inhibitor on pancreatic secretion and cholecystokinin release in conscious rats. Pancreas 4 139-44 PubMed GONUTS page
- ↑ Tsuzuki, S et al. (1992) Monitor peptide gene expression is increased by exogenous CCK in the rat pancreas and in a rat pancreatic acinar cell line (AR4-2J). FEBS Lett. 307 386-8 PubMed GONUTS page
- ↑ Fukuda, M et al. () Monitor peptide (rat pancreatic secretory trypsin inhibitor) directly stimulates the proliferation of the nontransformed intestinal epithelial cell line, IEC-6. Digestion 59 326-30 PubMed GONUTS page
- ↑ Li, HS et al. (2001) Chronic ethanol consumption induces gene expression of pancreatic monitor peptide, but not SPINK1/PSTI-56, in rats. Pancreas 23 117-24 PubMed GONUTS page
- ↑ Tsuzuki, S et al. (1991) Effect of a high-protein diet on the gene expression of a trypsin-sensitive, cholecystokinin-releasing peptide (monitor peptide) in the pancreas. Eur. J. Biochem. 199 245-52 PubMed GONUTS page
- ↑ Liddle, RA et al. (1992) Cholecystokinin cells purified by fluorescence-activated cell sorting respond to monitor peptide with an increase in intracellular calcium. Proc. Natl. Acad. Sci. U.S.A. 89 5147-51 PubMed GONUTS page
- ↑ Nathan, JD et al. (2005) Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice. Gastroenterology 128 717-27 PubMed GONUTS page
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- GO:0030414 ! peptidase inhibitor activity
- GO:0090187 ! positive regulation of pancreatic juice secretion
- GO:0090277 ! positive regulation of peptide hormone secretion
- GO:0007204 ! positive regulation of cytosolic calcium ion concentration
- GO:0050679 ! positive regulation of epithelial cell proliferation
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