GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com


Jump to: navigation, search

Fasulo, L, Ugolini, G and Cattaneo, A (2005) Apoptotic effect of caspase-3 cleaved tau in hippocampal neurons and its potentiation by tau FTDP-mutation N279K. J. Alzheimers Dis. 7:3-13


Pathological changes in the microtubule associated protein tau are a major hallmark of many human dementias collectively defined as tauopathies. In familiar frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), several mutations in the tau gene have been identified showing that primary malfunction of tau can lead to neurodegeneration. In addition to mutation at genetic level, a number of post-translational modifications of tau occur in tauopathies, including abnormal phosphorylation and aberrant proteolysis described in Alzheimer's Disease (AD). The presence of cleaved tau in AD neurons is associated with expression of markers for neuronal death. According to our previous work, tau is a substrate for the apoptotic protease caspase-3 that turns tau itself into an effector of apoptosis (tau cleaved at D-421), generating a positive-feedback loop that is self-propagating. Cleavage of tau by caspase-3 was recently confirmed to occur in AD brain as an early event. Here we show the apoptotic properties of tau fragment tau151-421 in primary cultures of rat hippocampal neurons; such cellular model is of special interest considering the selective vulnerability of hippocampal neurones in AD. The apoptotic capacity of tau151-421 is markedly enhanced by both treatment with amyloid peptide Abeta25-35, and the FTDP-17 tau mutation N279K.




Apoptosis/physiology; Caspase 3; Caspases/physiology; DNA Mutational Analysis; DNA Primers/genetics; Dementia/genetics; Dementia/metabolism; Fluorescent Antibody Technique; Hippocampus/metabolism; Humans; Microtubule-Associated Proteins/genetics; Neurons/metabolism; Point Mutation/genetics; Polymerase Chain Reaction; Tauopathies/genetics; Tauopathies/metabolism; Transfection; tau Proteins/physiology



Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status



GO:0006915: apoptotic process

ECO:0000314: direct assay evidence used in manual assertion


Seeded From UniProt


See also


See Help:References for how to manage references in GONUTS.