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PMID:15533241
| Citation |
Shaw, CA, Holland, PC, Sinnreich, M, Allen, C, Sollerbrant, K, Karpati, G and Nalbantoglu, J (2004) Isoform-specific expression of the Coxsackie and adenovirus receptor (CAR) in neuromuscular junction and cardiac intercalated discs. BMC Cell Biol. 5:42 |
|---|---|
| Abstract |
The Coxsackie and adenovirus receptor (CAR) has a restricted expression pattern in the adult. In skeletal muscle, although CAR is expressed in immature fibers, its transcript levels are barely detectable in mature muscle. This is in contrast to the robust expression observed in the heart. However, both heart and skeletal muscle are susceptible to infection with the Coxsackie B virus which utilizes primarily CAR for cellular internalization. The specific point of viral entry in skeletal and heart muscle remains unknown. |
| Links |
PubMed PMC533869 Online version:10.1186/1471-2121-5-42 |
| Keywords |
Amino Acid Sequence; Animals; Coxsackie and Adenovirus Receptor-Like Membrane Protein; Humans; Immunohistochemistry; Intercellular Junctions/metabolism; Mice; Molecular Sequence Data; Muscle, Skeletal/metabolism; Myocardium/metabolism; Neuromuscular Junction/chemistry; Neuromuscular Junction/metabolism; Protein Isoforms/analysis; Protein Isoforms/chemistry; Protein Isoforms/metabolism; Receptors, Virus/analysis; Receptors, Virus/chemistry; Receptors, Virus/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0031594: neuromuscular junction |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0014704: intercalated disc |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
See also
References
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