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PMID:1483394
Citation |
Rao, Y, Bodmer, R, Jan, LY and Jan, YN (1992) The big brain gene of Drosophila functions to control the number of neuronal precursors in the peripheral nervous system. Development 116:31-40 |
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Abstract |
big brain (bib) is one of the six known zygotic neurogenic genes involved in the decision of an ectodermal cell to take on the neurogenic or the epidermogenic cell fate. Previous studies suggest that bib functions in a pathway separate from the one involving Notch and other known neurogenic genes. For a better understanding of the bib function, it is essential first to characterize the mutant phenotype in detail. Our mutant analyses show that loss of bib function approximately doubles the number of neuronal precursors and their progeny cells in the embryonic peripheral nervous system. Mosaic studies reveal a hypertrophy of sensory bristles in bib mutant patches in adult flies. Our observations are compatible with a function of bib in specifying neuronal precursors of both the embryonic and adult sensory nervous system. This is in contrast to the function of Notch, which continues to be required at multiple stages of neural development subsequent to this initial determination event. |
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Keywords |
Animals; Cell Differentiation/genetics; Drosophila/anatomy & histology; Drosophila/embryology; Drosophila/genetics; Drosophila Proteins; Embryo, Nonmammalian/anatomy & histology; Genes, Insect/physiology; Membrane Proteins/genetics; Mutation/genetics; Neurons/physiology; Peripheral Nerves/embryology; Phenotype; Stem Cells/physiology |
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Significance
Annotations
Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
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GO:0007398: |
ECO:0000315: |
The hypertrophy effect of bib is shown to have an effect on the phenotype. Figure 1. Figure 2. |
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See also
References
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