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DROME:BIB

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) bib
Protein Name(s) Neurogenic protein big brain
External Links
UniProt P23645
EMBL X53275
AE014134
AY051981
PIR S09699
RefSeq NP_476837.1
UniGene Dm.3236
ProteinModelPortal P23645
SMR P23645
BioGrid 60424
DIP DIP-21188N
IntAct P23645
MINT MINT-1607360
STRING 7227.FBpp0079519
TCDB 1.A.8.8.3
PaxDb P23645
EnsemblMetazoa FBtr0079929
GeneID 34330
KEGG dme:Dmel_CG4722
CTD 34330
FlyBase FBgn0000180
eggNOG NOG325389
GeneTree ENSGT00760000119223
InParanoid P23645
OrthoDB EOG72NRQ0
PhylomeDB P23645
Reactome REACT_180274
REACT_180806
REACT_180810
REACT_204774
SignaLink P23645
GenomeRNAi 34330
NextBio 787982
Proteomes UP000000803
Bgee P23645
ExpressionAtlas P23645
GO GO:0005912
GO:0031410
GO:0016021
GO:0005886
GO:0005261
GO:0015267
GO:0098655
GO:0006812
GO:0007398
GO:0046331
GO:0007498
GO:0007399
GO:0007219
GO:0030707
GO:0044719
GO:0016337
GO:0055085
Gene3D 1.20.1080.10
InterPro IPR023271
IPR000425
IPR022357
PANTHER PTHR19139
Pfam PF00230
PRINTS PR00783
SUPFAM SSF81338
TIGRFAMs TIGR00861
PROSITE PS00221

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0007398

PMID:1483394[1]

ECO:0000315

The hypertrophy effect of bib is shown to have an effect on the phenotype.

Figure 1. Figure 2.

complete

part_of

GO:0016021

integral component of membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13270
FB:FBgn0000180
FB:FBgn0015872
MGI:MGI:103201
PANTHER:PTN000440616
RGD:2143
UniProtKB:P06624

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13270
FB:FBgn0000180
MGI:MGI:103201
MGI:MGI:106215
MGI:MGI:107387
MGI:MGI:1096865
MGI:MGI:96990
PANTHER:PTN000440616
RGD:2141
RGD:2142
RGD:2143
RGD:2144
RGD:3090
UniProtKB:K7N7A8
UniProtKB:P06624
UniProtKB:P29972
UniProtKB:P30301
UniProtKB:P41181
UniProtKB:P55064
UniProtKB:P55087
UniProtKB:Q5A1Z4

C

Seeded From UniProt

complete

involved_in

GO:0044719

regulation of imaginal disc-derived wing size

PMID:23232763[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|enables

GO:0005372

water transmembrane transporter activity

PMID:19467350[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0098609

cell-cell adhesion

PMID:19467350[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|enables

GO:0005216

ion channel activity

PMID:19467350[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:19467350[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

PMID:15800049[5]

ECO:0000250

sequence similarity evidence used in manual assertion

FB:FBgn0015872

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:15800049[5]

ECO:0000250

sequence similarity evidence used in manual assertion

FB:FBgn0015872

C

Seeded From UniProt

complete

enables

GO:0015267

channel activity

PMID:15800049[5]

ECO:0000250

sequence similarity evidence used in manual assertion

FB:FBgn0015872

F

Seeded From UniProt

complete

enables

GO:0005261

cation channel activity

PMID:11923418[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:9367444[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0046331

lateral inhibition

PMID:9367444[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005912

adherens junction

PMID:9367444[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

PMID:9367444[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007498

mesoderm development

PMID:1913825[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048665

neuron fate specification

PMID:9367444[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045747

positive regulation of Notch signaling pathway

PMID:9367444[7]

ECO:0000316

genetic interaction evidence used in manual assertion

FB:FBgn0000463

P

Seeded From UniProt

complete

involved_in

GO:0045747

positive regulation of Notch signaling pathway

PMID:9367444[7]

ECO:0000316

genetic interaction evidence used in manual assertion

FB:FBgn0004647

P

Seeded From UniProt

complete

involved_in

GO:0006833

water transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005372

P

Seeded From UniProt

complete

involved_in

GO:0034220

ion transmembrane transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005216

P

Seeded From UniProt

complete

involved_in

GO:0034220

ion transmembrane transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005261

P

Seeded From UniProt

complete

involved_in

GO:0098655

cation transmembrane transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005261

P

Seeded From UniProt

complete

enables

GO:0015267

channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000425

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000425

C

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000425

P

Seeded From UniProt

complete

involved_in

GO:0030707

ovarian follicle cell development

PMID:10822261[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007398

ectoderm development

PMID:1913825[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0524

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Rao, Y et al. (1992) The big brain gene of Drosophila functions to control the number of neuronal precursors in the peripheral nervous system. Development 116 31-40 PubMed GONUTS page
  2. ↑ 2.0 2.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ Djiane, A et al. (2013) Dissecting the mechanisms of Notch induced hyperplasia. EMBO J. 32 60-71 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Tatsumi, K et al. (2009) Drosophila big brain does not act as a water channel, but mediates cell adhesion. FEBS Lett. 583 2077-82 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Kaufmann, N et al. (2005) Developmental expression and biophysical characterization of a Drosophila melanogaster aquaporin. Am. J. Physiol., Cell Physiol. 289 C397-407 PubMed GONUTS page
  6. ↑ Yanochko, GM & Yool, AJ (2002) Regulated cationic channel function in Xenopus oocytes expressing Drosophila big brain. J. Neurosci. 22 2530-40 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Doherty, D et al. (1997) The Drosophila neurogenic gene big brain, which encodes a membrane-associated protein, acts cell autonomously and can act synergistically with Notch and Delta. Development 124 3881-93 PubMed GONUTS page
  8. ↑ 8.0 8.1 Corbin, V et al. (1991) A role for the Drosophila neurogenic genes in mesoderm differentiation. Cell 67 311-23 PubMed GONUTS page
  9. ↑ Dobens, LL & Raftery, LA (2000) Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells. Dev. Dyn. 218 80-93 PubMed GONUTS page
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