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DROME:BIB

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) bib
Protein Name(s) Neurogenic protein big brain
External Links
UniProt P23645
EMBL X53275
AE014134
AY051981
PIR S09699
RefSeq NP_476837.1
UniGene Dm.3236
ProteinModelPortal P23645
SMR P23645
BioGrid 60424
DIP DIP-21188N
IntAct P23645
MINT MINT-1607360
STRING 7227.FBpp0079519
TCDB 1.A.8.8.3
PaxDb P23645
EnsemblMetazoa FBtr0079929
GeneID 34330
KEGG dme:Dmel_CG4722
CTD 34330
FlyBase FBgn0000180
eggNOG NOG325389
GeneTree ENSGT00760000119223
InParanoid P23645
OrthoDB EOG72NRQ0
PhylomeDB P23645
Reactome REACT_180274
REACT_180806
REACT_180810
REACT_204774
SignaLink P23645
GenomeRNAi 34330
NextBio 787982
Proteomes UP000000803
Bgee P23645
ExpressionAtlas P23645
GO GO:0005912
GO:0031410
GO:0016021
GO:0005886
GO:0005261
GO:0015267
GO:0098655
GO:0006812
GO:0007398
GO:0046331
GO:0007498
GO:0007399
GO:0007219
GO:0030707
GO:0044719
GO:0016337
GO:0055085
Gene3D 1.20.1080.10
InterPro IPR023271
IPR000425
IPR022357
PANTHER PTHR19139
Pfam PF00230
PRINTS PR00783
SUPFAM SSF81338
TIGRFAMs TIGR00861
PROSITE PS00221

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0007398

PMID:1483394[1]

IMP: Inferred from Mutant Phenotype

The hypertrophy effect of bib is shown to have an effect on the phenotype.

Figure 1. Figure 2.

complete

GO:0005215

transporter activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000425
InterPro:IPR022357

F

Seeded From UniProt

complete

GO:0005261

cation channel activity

PMID:11923418[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:9367444[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005887

integral component of plasma membrane

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000440615

C

Seeded From UniProt

complete

GO:0005912

adherens junction

PMID:9367444[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006810

transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000425
InterPro:IPR022357

P

Seeded From UniProt

complete

GO:0006810

transport

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0813

P

Seeded From UniProt

complete

GO:0006811

ion transport

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

GO:0006812

cation transport

PMID:11923418[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0006833

water transport

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000440615

P

Seeded From UniProt

complete

GO:0007219

Notch signaling pathway

PMID:12127141[4]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007398

ectoderm development

PMID:1913825[5]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007399

nervous system development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0524

P

Seeded From UniProt

complete

GO:0007399

nervous system development

PMID:10929403[6]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007498

mesoderm development

PMID:1913825[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009992

cellular water homeostasis

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000440615

P

Seeded From UniProt

complete

GO:0015250

water channel activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000440615

F

Seeded From UniProt

complete

GO:0015254

glycerol channel activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000440615

F

Seeded From UniProt

complete

GO:0015267

channel activity

PMID:15800049[7]

ISS: Inferred from Sequence or Structural Similarity

FB:FBgn0015872

F

Seeded From UniProt

complete

GO:0015793

glycerol transport

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000440615

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000425
InterPro:IPR022357

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

PMID:15800049[7]

ISS: Inferred from Sequence or Structural Similarity

FB:FBgn0015872

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

PMID:19467350[8]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0016337

single organismal cell-cell adhesion

PMID:19467350[8]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0030154

cell differentiation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

GO:0030707

ovarian follicle cell development

PMID:10822261[9]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0031410

cytoplasmic vesicle

PMID:9367444[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0034220

ion transmembrane transport

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000440615

P

Seeded From UniProt

complete

GO:0044719

regulation of imaginal disc-derived wing size

PMID:23232763[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046331

lateral inhibition

PMID:19363474[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046331

lateral inhibition

PMID:9367444[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0055085

transmembrane transport

PMID:15800049[7]

ISS: Inferred from Sequence or Structural Similarity

FB:FBgn0015872

P

Seeded From UniProt

complete

GO:0098655

cation transmembrane transport

PMID:11923418[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

NOT

GO:0005216

ion channel activity

PMID:19467350[8]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

NOT

GO:0005372

water transmembrane transporter activity

PMID:19467350[8]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Rao, Y et al. (1992) The big brain gene of Drosophila functions to control the number of neuronal precursors in the peripheral nervous system. Development 116 31-40 PubMed GONUTS page
  2. 2.0 2.1 2.2 Yanochko, GM & Yool, AJ (2002) Regulated cationic channel function in Xenopus oocytes expressing Drosophila big brain. J. Neurosci. 22 2530-40 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Doherty, D et al. (1997) The Drosophila neurogenic gene big brain, which encodes a membrane-associated protein, acts cell autonomously and can act synergistically with Notch and Delta. Development 124 3881-93 PubMed GONUTS page
  4. Stewart, BA (2002) Membrane trafficking in Drosophila wing and eye development. Semin. Cell Dev. Biol. 13 91-7 PubMed GONUTS page
  5. 5.0 5.1 Corbin, V et al. (1991) A role for the Drosophila neurogenic genes in mesoderm differentiation. Cell 67 311-23 PubMed GONUTS page
  6. Kumar, JP & Moses, K (2000) Cell fate specification in the Drosophila retina. Results Probl Cell Differ 31 93-114 PubMed GONUTS page
  7. 7.0 7.1 7.2 Kaufmann, N et al. (2005) Developmental expression and biophysical characterization of a Drosophila melanogaster aquaporin. Am. J. Physiol., Cell Physiol. 289 C397-407 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Tatsumi, K et al. (2009) Drosophila big brain does not act as a water channel, but mediates cell adhesion. FEBS Lett. 583 2077-82 PubMed GONUTS page
  9. Dobens, LL & Raftery, LA (2000) Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells. Dev. Dyn. 218 80-93 PubMed GONUTS page
  10. Djiane, A et al. (2013) Dissecting the mechanisms of Notch induced hyperplasia. EMBO J. 32 60-71 PubMed GONUTS page
  11. Mummery-Widmer, JL et al. (2009) Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Nature 458 987-92 PubMed GONUTS page