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PMID:1448622
| Citation |
Wei, BY, Bradbeer, C and Kadner, RJ (1992) Conserved structural and regulatory regions in the Salmonella typhimurium btuB gene for the outer membrane vitamin B12 transport protein. Res. Microbiol. 143:459-66 |
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| Abstract |
The Salmonella typhimurium btuB gene encodes an outer membrane protein that is necessary for the transport of vitamin B12 and the uptake of the E colicins and bacteriophage BF23. The sequence of this gene showed 87% identity of the deduced polypeptide to its Escherichia coli homolog, and its product was found to function in transport as effectively in cells of E. coli as did the native protein. The extensive sequence conservation within the first 300 transcribed nucleotides, which include the leader and early part of the coding sequence, supports the proposed role of this region in the regulation of btuB gene expression. |
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| Keywords |
Bacterial Outer Membrane Proteins/genetics; Base Sequence/genetics; Biological Transport, Active/physiology; DNA, Bacterial/genetics; Escherichia coli/metabolism; Gene Expression Regulation, Bacterial; Genes, Bacterial/genetics; Molecular Sequence Data; Plasmids/genetics; Salmonella typhimurium/genetics; Salmonella typhimurium/metabolism; Vitamin B 12/pharmacokinetics |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005215: transporter activity |
ECO:0000315: |
F |
Fig 2. Plasmid pKB4 in RK5016 (BtuB transformed strain) conferred amplified levels of vitamin B12 binding and transport. |
complete | ||||
See also
References
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