PMID:1320959

Citation	Potier, MC, Spillantini, MG and Carter, NP (1992) The human glutamate receptor cDNA GluR1: cloning, sequencing, expression and localization to chromosome 5. DNA Seq. 2:211-8
Abstract	The rat glutamate receptor is a 907 amino acid transmembrane protein. Using the rat GluR1 cDNA as a probe, we have isolated cDNA clones from a human hippocampal cDNA library. Sequence of a full length cDNA clone revealed 98.2% and 89.4% identity to the rat sequence at the amino acid and nucleotide levels respectively. The human cDNA clone detected an RNA transcript in human cerebral cortex, hippocampus and cerebellum, similar to that seen in rat. In situ hybridization experiments showed that human GluR1 mRNA is present in granule and pyramidal cells in the hippocampal formation and that there is no apparent difference of distribution between control patient and patient with Alzheimer's disease. Dot blot analysis of flow-sorted human chromosomes showed that the GluR1 gene maps to chromosome 5.
Links	PubMed
Keywords	Aged; Aged, 80 and over; Alzheimer Disease/genetics; Alzheimer Disease/metabolism; Amino Acid Sequence; Animals; Base Sequence; Brain/metabolism; Chromosome Mapping; Chromosomes, Human, Pair 5; Cloning, Molecular; DNA/genetics; DNA Probes; Gene Expression; Glutamates/metabolism; Humans; Mice; Molecular Sequence Data; Rats; Receptors, Glutamate; Receptors, Neurotransmitter/genetics; Receptors, Neurotransmitter/metabolism; Sequence Homology, Nucleic Acid; Species Specificity
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:GRIA1	enables	GO:0008066: glutamate receptor activity	ECO:0000304: author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete

References

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