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HUMAN:GRIA1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | GRIA1 (synonyms: GLUH1, GLUR1) | |
Protein Name(s) | Glutamate receptor 1
GluR-1 AMPA-selective glutamate receptor 1 GluR-A GluR-K1 Glutamate receptor ionotropic, AMPA 1 GluA1 | |
External Links | ||
UniProt | P42261 | |
EMBL | M64752 X58633 M81886 AK295039 AK295184 AK295827 AK315934 AC010613 AC025156 AC091960 AC091962 CH471062 CH471062 BC111734 | |
CCDS | CCDS4322.1 CCDS47318.1 CCDS58986.1 CCDS58987.1 CCDS58988.1 CCDS58989.1 | |
PIR | A40222 A41273 S25852 S38723 | |
RefSeq | NP_000818.2 NP_001107655.1 NP_001244948.1 NP_001244950.1 NP_001244951.1 NP_001244952.1 | |
UniGene | Hs.519693 Hs.737709 | |
ProteinModelPortal | P42261 | |
SMR | P42261 | |
BioGrid | 109147 | |
DIP | DIP-41487N | |
MINT | MINT-271172 | |
STRING | 9606.ENSP00000285900 | |
BindingDB | P42261 | |
ChEMBL | CHEMBL2096670 | |
DrugBank | DB01189 DB00228 DB00753 DB01028 DB08883 DB01236 | |
GuidetoPHARMACOLOGY | 444 | |
PhosphoSite | P42261 | |
DMDM | 116242505 | |
PaxDb | P42261 | |
PRIDE | P42261 | |
Ensembl | ENST00000285900 ENST00000340592 ENST00000448073 ENST00000518142 ENST00000518783 ENST00000521843 | |
GeneID | 2890 | |
KEGG | hsa:2890 | |
UCSC | uc003luy.4 uc003lva.4 uc011dcw.2 | |
CTD | 2890 | |
GeneCards | GC05P152850 | |
H-InvDB | HIX0032120 | |
HGNC | HGNC:4571 | |
HPA | CAB001965 HPA035202 | |
MIM | 138248 | |
neXtProt | NX_P42261 | |
PharmGKB | PA28966 | |
eggNOG | NOG316680 | |
GeneTree | ENSGT00760000118920 | |
HOGENOM | HOG000234372 | |
HOVERGEN | HBG051839 | |
InParanoid | P42261 | |
KO | K05197 | |
OMA | MQRSFTI | |
OrthoDB | EOG7C2R0J | |
PhylomeDB | P42261 | |
TreeFam | TF315232 | |
Reactome | REACT_18307 REACT_18338 REACT_18422 REACT_20594 | |
SignaLink | P42261 | |
ChiTaRS | GRIA1 | |
GeneWiki | GRIA1 | |
GenomeRNAi | 2890 | |
NextBio | 11425 | |
PRO | PR:P42261 | |
Proteomes | UP000005640 | |
Bgee | P42261 | |
CleanEx | HS_GRIA1 | |
ExpressionAtlas | P42261 | |
Genevestigator | P42261 | |
GO | GO:0032281 GO:0044308 GO:0030054 GO:0009986 GO:0030425 GO:0032590 GO:0043197 GO:0032591 GO:0030666 GO:0005789 GO:0044309 GO:0043025 GO:0005886 GO:0014069 GO:0045211 GO:0055037 GO:0008021 GO:0004971 GO:0005234 GO:0008066 GO:0030165 GO:0034220 GO:0035235 GO:0007616 GO:0031623 GO:0007165 GO:0007268 GO:0035249 | |
InterPro | IPR001828 IPR019594 IPR001508 IPR001320 IPR028082 | |
Pfam | PF01094 PF00060 PF10613 | |
PRINTS | PR00177 | |
SMART | SM00918 SM00079 | |
SUPFAM | SSF53822 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
part_of |
GO:0097060 |
synaptic membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
part_of:(CL:0002608) |
Seeded From UniProt |
complete | ||
part_of |
GO:0014069 |
postsynaptic density |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
part_of:(UBERON:0000955) |
Seeded From UniProt |
complete | ||
part_of |
GO:0032591 |
dendritic spine membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0055037 |
recycling endosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0043197 |
dendritic spine |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
part_of:(CL:0002608) |
Seeded From UniProt |
complete | ||
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
part_of:(CL:0002608) |
Seeded From UniProt |
complete | ||
part_of |
GO:0030425 |
dendrite |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
part_of:(CL:0002608) |
Seeded From UniProt |
complete | ||
enables |
GO:0001540 |
amyloid-beta binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
occurs_in:(CL:0002608) |
Seeded From UniProt |
complete | ||
part_of |
GO:0044309 |
neuron spine |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0030165 |
PDZ domain binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0009986 |
cell surface |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0043197 |
dendritic spine |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0032281 |
AMPA glutamate receptor complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0030425 |
dendrite |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0014069 |
postsynaptic density |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004971 |
AMPA glutamate receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004971 |
AMPA glutamate receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0099583 |
neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95808 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0032281 |
AMPA glutamate receptor complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95808 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0004620 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004971 |
AMPA glutamate receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000438080 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0000139 |
Golgi membrane |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0048208 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034220 |
ion transmembrane transport |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005216 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035235 |
ionotropic glutamate receptor signaling pathway |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004970 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035235 |
ionotropic glutamate receptor signaling pathway |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004971 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035235 |
ionotropic glutamate receptor signaling pathway |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004971 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035235 |
ionotropic glutamate receptor signaling pathway |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004971 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0099566 |
regulation of postsynaptic cytosolic calcium ion concentration |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0099583 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0099566 |
regulation of postsynaptic cytosolic calcium ion concentration |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0099583 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:1904315 |
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0099583 |
neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0099061 |
integral component of postsynaptic density membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0098839 |
postsynaptic density membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0098794 |
postsynapse |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060292 |
long-term synaptic depression |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060078 |
regulation of postsynaptic membrane potential |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0045211 |
postsynaptic membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0045202 |
synapse |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0044309 |
neuron spine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0044308 |
axonal spine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0043197 |
dendritic spine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0043005 |
neuron projection |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0036477 |
somatodendritic compartment |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0032590 |
dendrite membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0032281 |
AMPA glutamate receptor complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031623 |
receptor internalization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0030425 |
dendrite |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0016020 |
membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0014069 |
postsynaptic density |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0009986 |
cell surface |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0008328 |
ionotropic glutamate receptor complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0008021 |
synaptic vesicle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007616 |
long-term memory |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007268 |
chemical synaptic transmission |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23818 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004970 |
ionotropic glutamate receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005216 |
ion channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006811 |
ion transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0038023 |
signaling receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008066 |
glutamate receptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007268 |
chemical synaptic transmission |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007165 |
signal transduction |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
PMID:1311100[6] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:2000310 |
regulation of NMDA receptor activity |
Reactome:R-HSA-438066 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048208 |
COPII vesicle coating |
Reactome:R-HSA-204005 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0033116 |
endoplasmic reticulum-Golgi intermediate compartment membrane |
Reactome:R-HSA-5694446 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0030666 |
endocytic vesicle membrane |
Reactome:R-HSA-421007 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0012507 |
ER to Golgi transport vesicle membrane |
Reactome:R-HSA-5694446 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0006888 |
endoplasmic reticulum to Golgi vesicle-mediated transport |
Reactome:R-HSA-199977 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
Reactome:R-HSA-5694527 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005768 |
endosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0045202 |
synapse |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006811 |
ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0045211 |
postsynaptic membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0043197 |
dendritic spine |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0055038 |
recycling endosome membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0031901 |
early endosome membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0014069 |
postsynaptic density |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0030425 |
dendrite |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Kennedy, MJ et al. (2010) Syntaxin-4 defines a domain for activity-dependent exocytosis in dendritic spines. Cell 141 524-35 PubMed GONUTS page
- ↑ Shi, Y et al. (2010) Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. Proc. Natl. Acad. Sci. U.S.A. 107 16315-9 PubMed GONUTS page
- ↑ Kato, AS et al. (2010) Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. Neuron 68 1082-96 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Potier, MC et al. (1992) The human glutamate receptor cDNA GluR1: cloning, sequencing, expression and localization to chromosome 5. DNA Seq. 2 211-8 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Sun, W et al. (1992) Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors. Proc. Natl. Acad. Sci. U.S.A. 89 1443-7 PubMed GONUTS page
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d
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- GO:0031901 ! early endosome membrane
- GO:0030666 ! endocytic vesicle membrane
- GO:0006888 ! endoplasmic reticulum to Golgi vesicle-mediated transport
- GO:0005789 ! endoplasmic reticulum membrane
- GO:0033116 ! endoplasmic reticulum-Golgi intermediate compartment membrane
- GO:0005783 ! endoplasmic reticulum
- GO:0005768 ! endosome
- GO:0012507 ! ER to Golgi transport vesicle membrane
- Euarchontoglires
- Eukaryota
- Euteleostomi
- Eutheria
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