PMID:12670687

Citation	Park, BC, Park, YH and Park, HM (2003) Activation of chsC transcription by AbaA during asexual development of Aspergillus nidulans. FEMS Microbiol. Lett. 220:241-6
Abstract	The temporal and spatial regulation of chitin synthesis plays an important role in morphogenesis during fungal growth and development. Northern blot analysis showed that the transcription level of chsA, chsC, and chsD was significantly decreased in an Aspergillus nidulans abaA mutant. Electrophoretic mobility shift assays revealed that AbaA bound tightly to all three AREs (AbaA response elements) in the chsC promoter region. Experiments with the Saccharomyces cerevisiae heterologous expression system confirmed AbaA-dependent transcriptional activation of chsC. Taken together, these data suggest that AbaA plays an important role in chitin biosynthesis during conidiophore development by controlling the transcription level of certain chitin synthase genes.
Links	PubMed
Keywords	Aspergillus nidulans/enzymology; Aspergillus nidulans/genetics; Aspergillus nidulans/physiology; Chitin/biosynthesis; Chitin Synthase/classification; Chitin Synthase/genetics; Chitin Synthase/metabolism; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Enzyme Induction; Fungal Proteins; Gene Expression Regulation, Bacterial; Glutathione Transferase/metabolism; Mutation; Reproduction, Asexual/genetics; Response Elements/genetics; Transcription Factors/genetics; Transcription Factors/metabolism; Transcriptional Activation; beta-Galactosidase/biosynthesis; beta-Galactosidase/metabolism
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
EMENI:ABAA	enables	GO:0044212: transcription regulatory region DNA binding	ECO:0000314: direct assay evidence used in manual assertion		F		Seeded From UniProt	complete

References

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