PMID:12617855

Citation	Suetsugu, R, Sato, Y and Takahashi, Y (2002) Pax 2 expression in mesodermal segmentation and its relationship with EphA4 and Lunatic-fringe during chicken somitogenesis. Gene Expr. Patterns 2:157-61
Abstract	In the Pax gene family, which encodes DNA-binding proteins, Pax 2 has been known to play important roles in the formation of the midbrain/hindbrain boundary, eye, inner ear and kidney in vertebrates (Bioessays 19 (1997) 755). In this article, we report a segmentally regulated pattern of Pax 2 expression during chicken somitogenesis. Pax 2 mRNA is localized in the rostral end of the unsegmented presomitic mesoderm (PSM), abutting anteriorly on a prospective segmentation border. This pattern repeats every segmentation cycle (90 min) observed in ovo and also in the half embryo culture assay in which one half of PSM along the midline is fixed immediately while the other half is cultured for a given period. We also determined the sequence of changes in Pax 2 expression during a segmentation cycle by comparing the pattern of Pax 2 with that of Lunatic-fringe (L-fringe), known to cycle periodically in posterior PSM. A systematic comparison of the expression patterns between Pax 2, L-fringe and EphA4 further highlighted a close relationship between EphA4 and Pax 2 during a segmentation cycle. Lastly, Pax 2 is not segmentally expressed in mouse PSM, suggestive of species (avian)-specific mechanisms underlying somitic segmentation.
Links	PubMed
Keywords	Animals; Avian Proteins; Chick Embryo; DNA-Binding Proteins/biosynthesis; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Gene Expression Profiling; Glycosyltransferases/metabolism; Mesoderm/metabolism; Mice/embryology; PAX2 Transcription Factor; Receptor, EphA4/metabolism; Somites/metabolism; Transcription Factors/biosynthesis; Transcription Factors/genetics; Transcription Factors/metabolism
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
CHICK:EPHA4	involved_in	GO:0001756: somitogenesis	ECO:0000303: author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
CHICK:EPHA4	involved_in	GO:0035282: segmentation	ECO:0000303: author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
CHICK:Q9PTX1	involved_in	GO:0001756: somitogenesis	ECO:0000303: author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
CHICK:Q9PTX1	involved_in	GO:0035282: segmentation	ECO:0000303: author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete

References

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