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PMID:12074933
| Citation |
Kowalska, K, Carr, DB and Lipkowski, AW (2002) Direct antimicrobial properties of substance P. Life Sci. 71:747-50 |
|---|---|
| Abstract |
The structural similarity between substance P (SP, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH(2)) and Arg/Pro rich bactericidal peptides suggests a possible direct effect of SP on invasive microbes. We now present evidence that substance P possesses direct antimicrobial activity, highest against S. aureus. A substance P antagonist also possesses such activity but while less potent than substance P agonist S. aureus, is more potent than substance P against C. albicans. Our data also show that the endogenous peptides bradykinin and neurotensin, that also play role in modulation of the host-defense system in situ, have antimicrobial properties but are less potent than substance P. |
| Links | |
| Keywords |
Adjuvants, Immunologic/pharmacology; Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Bacteria/drug effects; Candida albicans/drug effects; Microbial Sensitivity Tests; Peptides/pharmacology; Substance P/antagonists & inhibitors; Substance P/pharmacology |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0061844: antimicrobial humoral immune response mediated by antimicrobial peptide |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031640: killing of cells of other organism |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
Notes
See also
References
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