HUMAN:KNG1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	KNG1 (synonyms: BDK, KNG)
Protein Name(s)	Kininogen-1 Alpha-2-thiol proteinase inhibitor Fitzgerald factor High molecular weight kininogen HMWK Williams-Fitzgerald-Flaujeac factor Kininogen-1 heavy chain T-kinin Ile-Ser-Bradykinin Bradykinin Kallidin I Lysyl-bradykinin Kallidin II Kininogen-1 light chain Low molecular weight growth-promoting factor
External Links
UniProt	P01042
EMBL	K02566 M11437 M11438 M11521 M11522 M11523 M11524 M11525 M11526 M11527 M11528 M11437 M11438 M11521 M11522 M11523 M11524 M11525 M11526 M11527 M11528 AK315230 AK290839 AK223589 AY248697 AC109780 AC112907 CH471052 BC060039
CCDS	CCDS3281.1 CCDS43183.1 CCDS54695.1
PIR	A01279 A01280 S13279
RefSeq	NP_000884.1 NP_001095886.1 NP_001159923.1
UniGene	Hs.77741
PDB	1NY2 2WOK 4ASQ 4ASR 4ECB 4ECC 5I25
PDBsum	1NY2 2WOK 4ASQ 4ASR 4ECB 4ECC 5I25
ProteinModelPortal	P01042
SMR	P01042
BioGrid	110026
IntAct	P01042
MINT	MINT-1512276
STRING	9606.ENSP00000265023
BindingDB	P01042
ChEMBL	CHEMBL3638337
MEROPS	I25.016
iPTMnet	P01042
PhosphoSitePlus	P01042
BioMuta	KNG1
DMDM	124056474
SWISS-2DPAGE	P01042
PaxDb	P01042
PeptideAtlas	P01042
PRIDE	P01042
DNASU	3827
Ensembl	ENST00000265023 ENST00000287611 ENST00000447445
GeneID	3827
KEGG	hsa:3827
UCSC	uc003fqr.4
CTD	3827
DisGeNET	3827
EuPathDB	HostDB:ENSG00000113889.11
GeneCards	KNG1
HGNC	HGNC:6383
HPA	CAB009809 HPA001616 HPA001645
MalaCards	KNG1
MIM	228960 612358
neXtProt	NX_P01042
OpenTargets	ENSG00000113889
Orphanet	483
PharmGKB	PA225
eggNOG	ENOG410IKIQ ENOG4111ZQ8
GeneTree	ENSGT00440000039713
HOGENOM	HOG000113239
HOVERGEN	HBG006224
InParanoid	P01042
KO	K03898
OMA	GECTATV
OrthoDB	EOG091G0SH2
PhylomeDB	P01042
TreeFam	TF351852
Reactome	[www.reactome.org/content/detail/R-HSA-114608 R-HSA-114608] [www.reactome.org/content/detail/R-HSA-140837 R-HSA-140837] [www.reactome.org/content/detail/R-HSA-375276 R-HSA-375276] [www.reactome.org/content/detail/R-HSA-381426 R-HSA-381426] [www.reactome.org/content/detail/R-HSA-416476 R-HSA-416476] [www.reactome.org/content/detail/R-HSA-418594 R-HSA-418594] [www.reactome.org/content/detail/R-HSA-8957275 R-HSA-8957275]
ChiTaRS	KNG1
EvolutionaryTrace	P01042
GeneWiki	Kininogen_1
GenomeRNAi	3827
PMAP-CutDB	B2RCR2
PRO	PR:P01042
Proteomes	UP000005640
Bgee	ENSG00000113889
CleanEx	HS_KNG1
Genevisible	P01042
GO	GO:0072562 GO:0005788 GO:0070062 GO:0031012 GO:0005576 GO:0005615 GO:0005886 GO:0031093 GO:0004869 GO:0008201 GO:0005102 GO:0008270 GO:0061844 GO:0007597 GO:0044267 GO:0006954 GO:0031640 GO:0030195 GO:0007162 GO:0045861 GO:0002576 GO:0043065 GO:0007204 GO:0043687 GO:0042311
CDD	cd00042
InterPro	IPR000010 IPR002395 IPR027358 IPR018073
Pfam	PF00031
PRINTS	PR00334
SMART	SM00043
PROSITE	PS00287 PS51647

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28675934^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0003688)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:25037231^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:27068509^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0007318)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:27559042^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0006618) part_of:(UBERON:0002302)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0072562	blood microparticle	PMID:22516433^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
involved_in	GO:0045861	negative regulation of proteolysis	PMID:3488317^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:3488317^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
enables	GO:0004869	cysteine-type endopeptidase inhibitor activity	PMID:3488317^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P07858)	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:12715893^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030195	negative regulation of blood coagulation	PMID:11970955^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:12911595^[11]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:12911595^[11]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:16014619^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007162	negative regulation of cell adhesion	PMID:11970955^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:14718574^[13]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:11290596^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04264	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:11290596^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q03405	F		Seeded From UniProt	complete
involved_in	GO:0030195	negative regulation of blood coagulation	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000009491 UniProtKB:P01042	P		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1890221 PANTHER:PTN000352258	P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000009491 UniProtKB:P01042	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000352258 UniProtKB:P04196	C		Seeded From UniProt	complete
enables	GO:0004869	cysteine-type endopeptidase inhibitor activity	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000009491 RGD:2980 UniProtKB:P01042	F		Seeded From UniProt	complete
enables	GO:0004869	cysteine-type endopeptidase inhibitor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000010	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16502470^[16]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001914)	Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:12074933^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:12074933^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:12074933^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:12074933^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:12074933^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:12074933^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:12074933^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:12074933^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:12074933^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:12074933^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044267	cellular protein metabolic process	Reactome:R-HSA-392499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043687	post-translational protein modification	Reactome:R-HSA-597592	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031093	platelet alpha granule lumen	Reactome:R-HSA-481007	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007597	blood coagulation, intrinsic pathway	Reactome:R-HSA-140837	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-158354 Reactome:R-HSA-158313 Reactome:R-HSA-158311 Reactome:R-HSA-158251 Reactome:R-HSA-158218	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-8952289	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-749456 Reactome:R-HSA-749454 Reactome:R-HSA-749452 Reactome:R-HSA-749448 Reactome:R-HSA-481007 Reactome:R-HSA-380073 Reactome:R-HSA-379048 Reactome:R-HSA-374331 Reactome:R-HSA-158354 Reactome:R-HSA-158311	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002576	platelet degranulation	Reactome:R-HSA-114608	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042311	vasodilation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0840	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
involved_in	GO:0007599	hemostasis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0356	P		Seeded From UniProt	complete
enables	GO:0030414	peptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	F		Seeded From UniProt	complete
enables	GO:0004869	cysteine-type endopeptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0789	F		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0094	P		Seeded From UniProt	complete
involved_in	GO:0010466	negative regulation of peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	P		Seeded From UniProt	complete
involved_in	GO:0050880	regulation of blood vessel size	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0838	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0112	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
↑ Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Abrahamson, M et al. (1986) Isolation of six cysteine proteinase inhibitors from human urine. Their physicochemical and enzyme kinetic properties and concentrations in biological fluids. J. Biol. Chem. 261 11282-9 PubMed GONUTS page
↑ Al-Fakhri, N et al. (2003) Induction of apoptosis in vascular cells by plasminogen activator inhibitor-1 and high molecular weight kininogen correlates with their anti-adhesive properties. Biol. Chem. 384 423-35 PubMed GONUTS page
↑ ^10.0 ^10.1 Chavakis, T et al. (2002) Inhibition of platelet adhesion and aggregation by a defined region (Gly-486-Lys-502) of high molecular weight kininogen. J. Biol. Chem. 277 23157-64 PubMed GONUTS page
↑ ^11.0 ^11.1 Pixley, RA et al. (2003) Fine mapping of the sequences in domain 5 of high molecular weight kininogen (HK) interacting with heparin and zinc. J. Thromb. Haemost. 1 1791-8 PubMed GONUTS page
↑ Dong, YL et al. (2005) Ca2+ signaling in human fetoplacental vasculature: effect of CGRP on umbilical vein smooth muscle cytosolic Ca2+ concentration. Am. J. Physiol. Heart Circ. Physiol. 289 H960-7 PubMed GONUTS page
↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
↑ ^14.0 ^14.1 Mahdi, F et al. (2001) Expression and colocalization of cytokeratin 1 and urokinase plasminogen activator receptor on endothelial cells. Blood 97 2342-50 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 ^17.7 ^17.8 ^17.9 Kowalska, K et al. (2002) Direct antimicrobial properties of substance P. Life Sci. 71 747-50 PubMed GONUTS page

[PMID:28675934-1] Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page

[PMID:25037231-2] Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page

[PMID:27068509-3] Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page

[PMID:27559042-4] Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page

[PMID:23533145-5] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:22516433-6] Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page

[PMID:19056867-7] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:3488317-8] 8.0 ^8.1 ^8.2 Abrahamson, M et al. (1986) Isolation of six cysteine proteinase inhibitors from human urine. Their physicochemical and enzyme kinetic properties and concentrations in biological fluids. J. Biol. Chem. 261 11282-9 PubMed GONUTS page

[PMID:12715893-9] Al-Fakhri, N et al. (2003) Induction of apoptosis in vascular cells by plasminogen activator inhibitor-1 and high molecular weight kininogen correlates with their anti-adhesive properties. Biol. Chem. 384 423-35 PubMed GONUTS page

[PMID:11970955-10] 10.0 ^10.1 Chavakis, T et al. (2002) Inhibition of platelet adhesion and aggregation by a defined region (Gly-486-Lys-502) of high molecular weight kininogen. J. Biol. Chem. 277 23157-64 PubMed GONUTS page

[PMID:12911595-11] 11.0 ^11.1 Pixley, RA et al. (2003) Fine mapping of the sequences in domain 5 of high molecular weight kininogen (HK) interacting with heparin and zinc. J. Thromb. Haemost. 1 1791-8 PubMed GONUTS page

[PMID:16014619-12] Dong, YL et al. (2005) Ca2+ signaling in human fetoplacental vasculature: effect of CGRP on umbilical vein smooth muscle cytosolic Ca2+ concentration. Am. J. Physiol. Heart Circ. Physiol. 289 H960-7 PubMed GONUTS page

[PMID:14718574-13] Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page

[PMID:11290596-14] 14.0 ^14.1 Mahdi, F et al. (2001) Expression and colocalization of cytokeratin 1 and urokinase plasminogen activator receptor on endothelial cells. Blood 97 2342-50 PubMed GONUTS page

[PMID:21873635-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16502470-16] Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page

[PMID:12074933-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 ^17.7 ^17.8 ^17.9 Kowalska, K et al. (2002) Direct antimicrobial properties of substance P. Life Sci. 71 747-50 PubMed GONUTS page

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HUMAN:KNG1

Contents

Annotations

Notes

References

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