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HUMAN:KNG1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) KNG1 (synonyms: BDK, KNG)
Protein Name(s) Kininogen-1

Alpha-2-thiol proteinase inhibitor Fitzgerald factor High molecular weight kininogen HMWK Williams-Fitzgerald-Flaujeac factor Kininogen-1 heavy chain T-kinin Ile-Ser-Bradykinin Bradykinin Kallidin I Lysyl-bradykinin Kallidin II Kininogen-1 light chain Low molecular weight growth-promoting factor

External Links
UniProt P01042
EMBL K02566
M11437
M11438
M11521
M11522
M11523
M11524
M11525
M11526
M11527
M11528
M11437
M11438
M11521
M11522
M11523
M11524
M11525
M11526
M11527
M11528
AK315230
AK290839
AK223589
AY248697
AC109780
AC112907
CH471052
BC060039
CCDS CCDS3281.1
CCDS43183.1
CCDS54695.1
PIR A01279
A01280
S13279
RefSeq NP_000884.1
NP_001095886.1
NP_001159923.1
UniGene Hs.77741
PDB 1NY2
2WOK
4ASQ
4ASR
4ECB
4ECC
5I25
PDBsum 1NY2
2WOK
4ASQ
4ASR
4ECB
4ECC
5I25
ProteinModelPortal P01042
SMR P01042
BioGrid 110026
IntAct P01042
MINT MINT-1512276
STRING 9606.ENSP00000265023
BindingDB P01042
ChEMBL CHEMBL3638337
MEROPS I25.016
iPTMnet P01042
PhosphoSitePlus P01042
BioMuta KNG1
DMDM 124056474
SWISS-2DPAGE P01042
PaxDb P01042
PeptideAtlas P01042
PRIDE P01042
DNASU 3827
Ensembl ENST00000265023
ENST00000287611
ENST00000447445
GeneID 3827
KEGG hsa:3827
UCSC uc003fqr.4
CTD 3827
DisGeNET 3827
EuPathDB HostDB:ENSG00000113889.11
GeneCards KNG1
HGNC HGNC:6383
HPA CAB009809
HPA001616
HPA001645
MalaCards KNG1
MIM 228960
612358
neXtProt NX_P01042
OpenTargets ENSG00000113889
Orphanet 483
PharmGKB PA225
eggNOG ENOG410IKIQ
ENOG4111ZQ8
GeneTree ENSGT00440000039713
HOGENOM HOG000113239
HOVERGEN HBG006224
InParanoid P01042
KO K03898
OMA GECTATV
OrthoDB EOG091G0SH2
PhylomeDB P01042
TreeFam TF351852
Reactome [www.reactome.org/content/detail/R-HSA-114608 R-HSA-114608]
[www.reactome.org/content/detail/R-HSA-140837 R-HSA-140837]
[www.reactome.org/content/detail/R-HSA-375276 R-HSA-375276]
[www.reactome.org/content/detail/R-HSA-381426 R-HSA-381426]
[www.reactome.org/content/detail/R-HSA-416476 R-HSA-416476]
[www.reactome.org/content/detail/R-HSA-418594 R-HSA-418594]
[www.reactome.org/content/detail/R-HSA-8957275 R-HSA-8957275]
ChiTaRS KNG1
EvolutionaryTrace P01042
GeneWiki Kininogen_1
GenomeRNAi 3827
PMAP-CutDB B2RCR2
PRO PR:P01042
Proteomes UP000005640
Bgee ENSG00000113889
CleanEx HS_KNG1
Genevisible P01042
GO GO:0072562
GO:0005788
GO:0070062
GO:0031012
GO:0005576
GO:0005615
GO:0005886
GO:0031093
GO:0004869
GO:0008201
GO:0005102
GO:0008270
GO:0061844
GO:0007597
GO:0044267
GO:0006954
GO:0031640
GO:0030195
GO:0007162
GO:0045861
GO:0002576
GO:0043065
GO:0007204
GO:0043687
GO:0042311
CDD cd00042
InterPro IPR000010
IPR002395
IPR027358
IPR018073
Pfam PF00031
PRINTS PR00334
SMART SM00043
PROSITE PS00287
PS51647

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:28675934[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0003688)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:25037231[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0002107)

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:27068509[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0007318)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:27559042[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0006618)
  • part_of:(UBERON:0002302)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0072562

blood microparticle

PMID:22516433[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

involved_in

GO:0045861

negative regulation of proteolysis

PMID:3488317[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:3488317[8]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

enables

GO:0004869

cysteine-type endopeptidase inhibitor activity

PMID:3488317[8]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(UniProtKB:P07858)

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:12715893[9]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030195

negative regulation of blood coagulation

PMID:11970955[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

PMID:12911595[11]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

PMID:12911595[11]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:16014619[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007162

negative regulation of cell adhesion

PMID:11970955[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:14718574[13]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:11290596[14]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P04264

F

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:11290596[14]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q03405

F

Seeded From UniProt

complete

involved_in

GO:0030195

negative regulation of blood coagulation

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000009491
UniProtKB:P01042

P

Seeded From UniProt

complete

involved_in

GO:0010951

negative regulation of endopeptidase activity

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1890221
PANTHER:PTN000352258

P

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000009491
UniProtKB:P01042

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000352258
UniProtKB:P04196

C

Seeded From UniProt

complete

enables

GO:0004869

cysteine-type endopeptidase inhibitor activity

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000009491
RGD:2980
UniProtKB:P01042

F

Seeded From UniProt

complete

enables

GO:0004869

cysteine-type endopeptidase inhibitor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000010

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:16502470[16]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001914)

Seeded From UniProt

complete

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:12074933[17]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:12074933[17]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:12074933[17]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:12074933[17]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:12074933[17]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

PMID:12074933[17]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

PMID:12074933[17]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

PMID:12074933[17]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

PMID:12074933[17]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

PMID:12074933[17]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0044267

cellular protein metabolic process

Reactome:R-HSA-392499

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043687

post-translational protein modification

Reactome:R-HSA-597592

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031093

platelet alpha granule lumen

Reactome:R-HSA-481007

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007597

blood coagulation, intrinsic pathway

Reactome:R-HSA-140837

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-158354
Reactome:R-HSA-158313
Reactome:R-HSA-158311
Reactome:R-HSA-158251
Reactome:R-HSA-158218

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

part_of

GO:0005788

endoplasmic reticulum lumen

Reactome:R-HSA-8952289

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-749456
Reactome:R-HSA-749454
Reactome:R-HSA-749452
Reactome:R-HSA-749448
Reactome:R-HSA-481007
Reactome:R-HSA-380073
Reactome:R-HSA-379048
Reactome:R-HSA-374331
Reactome:R-HSA-158354
Reactome:R-HSA-158311

ECO:0000304

author statement supported by traceable reference used in manual assertion










C

Seeded From UniProt

complete

involved_in

GO:0002576

platelet degranulation

Reactome:R-HSA-114608

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042311

vasodilation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0840

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0395

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

involved_in

GO:0007599

hemostasis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0356

P

Seeded From UniProt

complete

enables

GO:0030414

peptidase inhibitor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0646

F

Seeded From UniProt

complete

enables

GO:0004869

cysteine-type endopeptidase inhibitor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0789

F

Seeded From UniProt

complete

involved_in

GO:0007596

blood coagulation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0094

P

Seeded From UniProt

complete

involved_in

GO:0010466

negative regulation of peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0646

P

Seeded From UniProt

complete

involved_in

GO:0050880

regulation of blood vessel size

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0838

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0112

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
  2. Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
  3. Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
  4. Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page
  5. Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  6. Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page
  7. Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  8. 8.0 8.1 8.2 Abrahamson, M et al. (1986) Isolation of six cysteine proteinase inhibitors from human urine. Their physicochemical and enzyme kinetic properties and concentrations in biological fluids. J. Biol. Chem. 261 11282-9 PubMed GONUTS page
  9. Al-Fakhri, N et al. (2003) Induction of apoptosis in vascular cells by plasminogen activator inhibitor-1 and high molecular weight kininogen correlates with their anti-adhesive properties. Biol. Chem. 384 423-35 PubMed GONUTS page
  10. 10.0 10.1 Chavakis, T et al. (2002) Inhibition of platelet adhesion and aggregation by a defined region (Gly-486-Lys-502) of high molecular weight kininogen. J. Biol. Chem. 277 23157-64 PubMed GONUTS page
  11. 11.0 11.1 Pixley, RA et al. (2003) Fine mapping of the sequences in domain 5 of high molecular weight kininogen (HK) interacting with heparin and zinc. J. Thromb. Haemost. 1 1791-8 PubMed GONUTS page
  12. Dong, YL et al. (2005) Ca2+ signaling in human fetoplacental vasculature: effect of CGRP on umbilical vein smooth muscle cytosolic Ca2+ concentration. Am. J. Physiol. Heart Circ. Physiol. 289 H960-7 PubMed GONUTS page
  13. Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
  14. 14.0 14.1 Mahdi, F et al. (2001) Expression and colocalization of cytokeratin 1 and urokinase plasminogen activator receptor on endothelial cells. Blood 97 2342-50 PubMed GONUTS page
  15. 15.0 15.1 15.2 15.3 15.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  16. Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
  17. 17.0 17.1 17.2 17.3 17.4 17.5 17.6 17.7 17.8 17.9 Kowalska, K et al. (2002) Direct antimicrobial properties of substance P. Life Sci. 71 747-50 PubMed GONUTS page