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HUMAN:KNG1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | KNG1 (synonyms: BDK, KNG) | |
Protein Name(s) | Kininogen-1
Alpha-2-thiol proteinase inhibitor Fitzgerald factor High molecular weight kininogen HMWK Williams-Fitzgerald-Flaujeac factor Kininogen-1 heavy chain T-kinin Ile-Ser-Bradykinin Bradykinin Kallidin I Lysyl-bradykinin Kallidin II Kininogen-1 light chain Low molecular weight growth-promoting factor | |
External Links | ||
UniProt | P01042 | |
EMBL | K02566 M11437 M11438 M11521 M11522 M11523 M11524 M11525 M11526 M11527 M11528 M11437 M11438 M11521 M11522 M11523 M11524 M11525 M11526 M11527 M11528 AK315230 AK290839 AK223589 AY248697 AC109780 AC112907 CH471052 BC060039 | |
CCDS | CCDS3281.1 CCDS43183.1 CCDS54695.1 | |
PIR | A01279 A01280 S13279 | |
RefSeq | NP_000884.1 NP_001095886.1 NP_001159923.1 | |
UniGene | Hs.77741 | |
PDB | 1NY2 2WOK 4ASQ 4ASR 4ECB 4ECC 5I25 | |
PDBsum | 1NY2 2WOK 4ASQ 4ASR 4ECB 4ECC 5I25 | |
ProteinModelPortal | P01042 | |
SMR | P01042 | |
BioGrid | 110026 | |
IntAct | P01042 | |
MINT | MINT-1512276 | |
STRING | 9606.ENSP00000265023 | |
BindingDB | P01042 | |
ChEMBL | CHEMBL3638337 | |
MEROPS | I25.016 | |
iPTMnet | P01042 | |
PhosphoSitePlus | P01042 | |
BioMuta | KNG1 | |
DMDM | 124056474 | |
SWISS-2DPAGE | P01042 | |
PaxDb | P01042 | |
PeptideAtlas | P01042 | |
PRIDE | P01042 | |
DNASU | 3827 | |
Ensembl | ENST00000265023 ENST00000287611 ENST00000447445 | |
GeneID | 3827 | |
KEGG | hsa:3827 | |
UCSC | uc003fqr.4 | |
CTD | 3827 | |
DisGeNET | 3827 | |
EuPathDB | HostDB:ENSG00000113889.11 | |
GeneCards | KNG1 | |
HGNC | HGNC:6383 | |
HPA | CAB009809 HPA001616 HPA001645 | |
MalaCards | KNG1 | |
MIM | 228960 612358 | |
neXtProt | NX_P01042 | |
OpenTargets | ENSG00000113889 | |
Orphanet | 483 | |
PharmGKB | PA225 | |
eggNOG | ENOG410IKIQ ENOG4111ZQ8 | |
GeneTree | ENSGT00440000039713 | |
HOGENOM | HOG000113239 | |
HOVERGEN | HBG006224 | |
InParanoid | P01042 | |
KO | K03898 | |
OMA | GECTATV | |
OrthoDB | EOG091G0SH2 | |
PhylomeDB | P01042 | |
TreeFam | TF351852 | |
Reactome | [www.reactome.org/content/detail/R-HSA-114608 R-HSA-114608] [www.reactome.org/content/detail/R-HSA-140837 R-HSA-140837] [www.reactome.org/content/detail/R-HSA-375276 R-HSA-375276] [www.reactome.org/content/detail/R-HSA-381426 R-HSA-381426] [www.reactome.org/content/detail/R-HSA-416476 R-HSA-416476] [www.reactome.org/content/detail/R-HSA-418594 R-HSA-418594] [www.reactome.org/content/detail/R-HSA-8957275 R-HSA-8957275] | |
ChiTaRS | KNG1 | |
EvolutionaryTrace | P01042 | |
GeneWiki | Kininogen_1 | |
GenomeRNAi | 3827 | |
PMAP-CutDB | B2RCR2 | |
PRO | PR:P01042 | |
Proteomes | UP000005640 | |
Bgee | ENSG00000113889 | |
CleanEx | HS_KNG1 | |
Genevisible | P01042 | |
GO | GO:0072562 GO:0005788 GO:0070062 GO:0031012 GO:0005576 GO:0005615 GO:0005886 GO:0031093 GO:0004869 GO:0008201 GO:0005102 GO:0008270 GO:0061844 GO:0007597 GO:0044267 GO:0006954 GO:0031640 GO:0030195 GO:0007162 GO:0045861 GO:0002576 GO:0043065 GO:0007204 GO:0043687 GO:0042311 | |
CDD | cd00042 | |
InterPro | IPR000010 IPR002395 IPR027358 IPR018073 | |
Pfam | PF00031 | |
PRINTS | PR00334 | |
SMART | SM00043 | |
PROSITE | PS00287 PS51647 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0003688) |
Seeded From UniProt |
complete | ||
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0002107) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005576 |
extracellular region |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0007318) |
Seeded From UniProt |
complete | ||
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0072562 |
blood microparticle |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045861 |
negative regulation of proteolysis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
enables |
GO:0004869 |
cysteine-type endopeptidase inhibitor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(UniProtKB:P07858) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030195 |
negative regulation of blood coagulation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008270 |
zinc ion binding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008201 |
heparin binding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007162 |
negative regulation of cell adhesion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030195 |
negative regulation of blood coagulation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000009491 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010951 |
negative regulation of endopeptidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1890221 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000009491 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005576 |
extracellular region |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000352258 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004869 |
cysteine-type endopeptidase inhibitor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000009491 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004869 |
cysteine-type endopeptidase inhibitor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005615 |
extracellular space |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001914) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0061844 |
antimicrobial humoral immune response mediated by antimicrobial peptide |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0061844 |
antimicrobial humoral immune response mediated by antimicrobial peptide |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0061844 |
antimicrobial humoral immune response mediated by antimicrobial peptide |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0061844 |
antimicrobial humoral immune response mediated by antimicrobial peptide |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0061844 |
antimicrobial humoral immune response mediated by antimicrobial peptide |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031640 |
killing of cells of other organism |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031640 |
killing of cells of other organism |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031640 |
killing of cells of other organism |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031640 |
killing of cells of other organism |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031640 |
killing of cells of other organism |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0044267 |
cellular protein metabolic process |
Reactome:R-HSA-392499 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043687 |
post-translational protein modification |
Reactome:R-HSA-597592 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0031093 |
platelet alpha granule lumen |
Reactome:R-HSA-481007 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007597 |
blood coagulation, intrinsic pathway |
Reactome:R-HSA-140837 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
Reactome:R-HSA-388396 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-158354 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0005788 |
endoplasmic reticulum lumen |
Reactome:R-HSA-8952289 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-749456 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0002576 |
platelet degranulation |
Reactome:R-HSA-114608 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042311 |
vasodilation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007599 |
hemostasis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0030414 |
peptidase inhibitor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004869 |
cysteine-type endopeptidase inhibitor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007596 |
blood coagulation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010466 |
negative regulation of peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050880 |
regulation of blood vessel size |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005615 |
extracellular space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
- ↑ Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
- ↑ Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
- ↑ Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Abrahamson, M et al. (1986) Isolation of six cysteine proteinase inhibitors from human urine. Their physicochemical and enzyme kinetic properties and concentrations in biological fluids. J. Biol. Chem. 261 11282-9 PubMed GONUTS page
- ↑ Al-Fakhri, N et al. (2003) Induction of apoptosis in vascular cells by plasminogen activator inhibitor-1 and high molecular weight kininogen correlates with their anti-adhesive properties. Biol. Chem. 384 423-35 PubMed GONUTS page
- ↑ 10.0 10.1 Chavakis, T et al. (2002) Inhibition of platelet adhesion and aggregation by a defined region (Gly-486-Lys-502) of high molecular weight kininogen. J. Biol. Chem. 277 23157-64 PubMed GONUTS page
- ↑ 11.0 11.1 Pixley, RA et al. (2003) Fine mapping of the sequences in domain 5 of high molecular weight kininogen (HK) interacting with heparin and zinc. J. Thromb. Haemost. 1 1791-8 PubMed GONUTS page
- ↑ Dong, YL et al. (2005) Ca2+ signaling in human fetoplacental vasculature: effect of CGRP on umbilical vein smooth muscle cytosolic Ca2+ concentration. Am. J. Physiol. Heart Circ. Physiol. 289 H960-7 PubMed GONUTS page
- ↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
- ↑ 14.0 14.1 Mahdi, F et al. (2001) Expression and colocalization of cytokeratin 1 and urokinase plasminogen activator receptor on endothelial cells. Blood 97 2342-50 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 15.3 15.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
- ↑ 17.0 17.1 17.2 17.3 17.4 17.5 17.6 17.7 17.8 17.9 Kowalska, K et al. (2002) Direct antimicrobial properties of substance P. Life Sci. 71 747-50 PubMed GONUTS page
b
c
e
n
p
- GO:0030414 ! peptidase inhibitor activity
- GO:0005886 ! plasma membrane
- GO:0031093 ! platelet alpha granule lumen
- GO:0002576 ! platelet degranulation
- GO:0007204 ! positive regulation of cytosolic calcium ion concentration
- GO:0043065 ! positive regulation of apoptotic process
- GO:0043687 ! post-translational protein modification
- Primates