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PMID:10858262
| Citation |
Lai, XH, Arencibia, I, Johansson, A, Wai, SN, Oscarsson, J, Kalfas, S, Sundqvist, KG, Mizunoe, Y, Sjöstedt, A and Uhlin, BE (2000) Cytocidal and apoptotic effects of the ClyA protein from Escherichia coli on primary and cultured monocytes and macrophages. Infect. Immun. 68:4363-7 |
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| Abstract |
Cytolysin A (ClyA) is a newly discovered cytolytic protein of Escherichia coli K-12 that mediates a hemolytic phenotype. We show here that highly purified ClyA and ClyA-expressing E. coli were cytotoxic and apoptogenic to fresh as well as cultured human and murine monocytes/macrophages. |
| Links | |
| Keywords |
Animals; Apoptosis/drug effects; Cell Death/drug effects; Cell Line; DNA Fragmentation/drug effects; Escherichia coli/genetics; Escherichia coli/pathogenicity; Escherichia coli Proteins; Hemolysin Proteins/genetics; Hemolysin Proteins/isolation & purification; Hemolysin Proteins/toxicity; Humans; In Vitro Techniques; Macrophages/drug effects; Macrophages/pathology; Mice; Monocytes/drug effects; Monocytes/pathology; U937 Cells |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0009405: pathogenesis |
ECO:0000315: |
P |
Figure 1: Cytotoxicity as manifested by LDH release from murine macrophages J774. Figure 2: The viability of freshly isolated human peripheral monocytes showed a dose-related decline after treatment with ClyA for 20 h |
complete | ||||
|
involved_in |
GO:0051715: cytolysis in other organism |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405: pathogenesis |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044532: modulation of apoptotic process in other organism |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
Notes
See also
References
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