GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
ECOLI:HLYE
Contents
| Species (Taxon ID) | Escherichia coli (strain K12). (83333) | |
| Gene Name(s) | hlyE (synonyms: clyA, hpr, sheA, ycgD) | |
| Protein Name(s) | Hemolysin E, chromosomal
Cytotoxin ClyA Hemolysis-inducing protein Latent pore-forming 34 kDa hemolysin Silent hemolysin SheA | |
| External Links | ||
| UniProt | P77335 | |
| EMBL | U57430 X98615 AJ001829 U73842 U00096 AP009048 AF240780 U22466 U13610 | |
| PIR | C64864 | |
| RefSeq | NP_415700.4 YP_489449.1 | |
| PDB | 1QOY 2WCD 4PHO 4PHQ | |
| PDBsum | 1QOY 2WCD 4PHO 4PHQ | |
| ProteinModelPortal | P77335 | |
| SMR | P77335 | |
| DIP | DIP-9915N | |
| MINT | MINT-2737936 | |
| STRING | 511145.b1182 | |
| TCDB | 1.C.10.1.1 | |
| EnsemblBacteria | AAC74266 BAA36016 | |
| GeneID | 12931106 945745 | |
| KEGG | ecj:Y75_p1154 eco:b1182 | |
| PATRIC | 32117610 | |
| EchoBASE | EB3032 | |
| EcoGene | EG13243 | |
| eggNOG | NOG72512 | |
| HOGENOM | HOG000051663 | |
| InParanoid | P77335 | |
| KO | K11139 | |
| OMA | KTVQNFF | |
| OrthoDB | EOG6XWV0P | |
| BioCyc | EcoCyc:G6619-MONOMER ECOL316407:JW5181-MONOMER | |
| EvolutionaryTrace | P77335 | |
| PRO | PR:P77335 | |
| Proteomes | UP000000318 UP000000625 | |
| Genevestigator | P77335 | |
| GO | GO:0005576 GO:0020002 GO:0016021 GO:0042597 GO:0042802 GO:0051715 GO:0044179 GO:0044532 GO:0009405 | |
| InterPro | IPR027018 | |
| Pfam | PF06109 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0009405 |
pathogenesis |
ECO:0000315 |
P |
Figure 1: Cytotoxicity as manifested by LDH release from murine macrophages J774. Figure 2: The viability of freshly isolated human peripheral monocytes showed a dose-related decline after treatment with ClyA for 20 h |
complete | |||||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044532 |
modulation of apoptotic process in other organism |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051715 |
cytolysis in other organism |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044179 |
hemolysis in other organism |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042597 |
periplasmic space |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044179 |
hemolysis in other organism |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0020002 |
host cell plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019835 |
cytolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0090729 |
toxin activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044179 |
hemolysis in other organism |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042597 |
periplasmic space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033644 |
host cell membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Lai, XH et al. (2000) Cytocidal and apoptotic effects of the ClyA protein from Escherichia coli on primary and cultured monocytes and macrophages. Infect. Immun. 68 4363-7 PubMed GONUTS page
- ↑ Mueller, M et al. (2009) The structure of a cytolytic alpha-helical toxin pore reveals its assembly mechanism. Nature 459 726-30 PubMed GONUTS page
- ↑ Eifler, N et al. (2006) Cytotoxin ClyA from Escherichia coli assembles to a 13-meric pore independent of its redox-state. EMBO J. 25 2652-61 PubMed GONUTS page
- ↑ del Castillo, FJ et al. (1997) The Escherichia coli K-12 sheA gene encodes a 34-kDa secreted haemolysin. Mol. Microbiol. 25 107-15 PubMed GONUTS page
- ↑ 5.0 5.1 Ludwig, A et al. (1999) Analysis of the SlyA-controlled expression, subcellular localization and pore-forming activity of a 34 kDa haemolysin (ClyA) from Escherichia coli K-12. Mol. Microbiol. 31 557-67 PubMed GONUTS page
