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ECOLI:HLYE

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) hlyE (synonyms: clyA, hpr, sheA, ycgD)
Protein Name(s) Hemolysin E, chromosomal

Cytotoxin ClyA Hemolysis-inducing protein Latent pore-forming 34 kDa hemolysin Silent hemolysin SheA

External Links
UniProt P77335
EMBL U57430
X98615
AJ001829
U73842
U00096
AP009048
AF240780
U22466
U13610
PIR C64864
RefSeq NP_415700.4
YP_489449.1
PDB 1QOY
2WCD
4PHO
4PHQ
PDBsum 1QOY
2WCD
4PHO
4PHQ
ProteinModelPortal P77335
SMR P77335
DIP DIP-9915N
MINT MINT-2737936
STRING 511145.b1182
TCDB 1.C.10.1.1
EnsemblBacteria AAC74266
BAA36016
GeneID 12931106
945745
KEGG ecj:Y75_p1154
eco:b1182
PATRIC 32117610
EchoBASE EB3032
EcoGene EG13243
eggNOG NOG72512
HOGENOM HOG000051663
InParanoid P77335
KO K11139
OMA KTVQNFF
OrthoDB EOG6XWV0P
BioCyc EcoCyc:G6619-MONOMER
ECOL316407:JW5181-MONOMER
EvolutionaryTrace P77335
PRO PR:P77335
Proteomes UP000000318
UP000000625
Genevestigator P77335
GO GO:0005576
GO:0020002
GO:0016021
GO:0042597
GO:0042802
GO:0051715
GO:0044179
GO:0044532
GO:0009405
InterPro IPR027018
Pfam PF06109

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0009405

pathogenesis

PMID:10858262[1]

ECO:0000315

P

Figure 1: Cytotoxicity as manifested by LDH release from murine macrophages J774. Figure 2: The viability of freshly isolated human peripheral monocytes showed a dose-related decline after treatment with ClyA for 20 h

complete
CACAO 10704

enables

GO:0042802

identical protein binding

PMID:19421192[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P77335

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:16688219[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P77335

F

Seeded From UniProt

complete

involved_in

GO:0044532

modulation of apoptotic process in other organism

PMID:10858262[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

PMID:10858262[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051715

cytolysis in other organism

PMID:10858262[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0044179

hemolysis in other organism

PMID:11902713[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0042597

periplasmic space

PMID:10027972[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:10027972[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027018

P

Seeded From UniProt

complete

involved_in

GO:0044179

hemolysis in other organism

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027018

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0020002

host cell plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1032
UniProtKB-SubCell:SL-0375

C

Seeded From UniProt

complete

involved_in

GO:0019835

cytolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0204

P

Seeded From UniProt

complete

enables

GO:0090729

toxin activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0800

F

Seeded From UniProt

complete

involved_in

GO:0044179

hemolysis in other organism

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0354

P

Seeded From UniProt

complete

part_of

GO:0042597

periplasmic space

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0574
UniProtKB-SubCell:SL-0200

C

Seeded From UniProt

complete

part_of

GO:0033644

host cell membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1043

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Lai, XH et al. (2000) Cytocidal and apoptotic effects of the ClyA protein from Escherichia coli on primary and cultured monocytes and macrophages. Infect. Immun. 68 4363-7 PubMed GONUTS page
  2. Mueller, M et al. (2009) The structure of a cytolytic alpha-helical toxin pore reveals its assembly mechanism. Nature 459 726-30 PubMed GONUTS page
  3. Eifler, N et al. (2006) Cytotoxin ClyA from Escherichia coli assembles to a 13-meric pore independent of its redox-state. EMBO J. 25 2652-61 PubMed GONUTS page
  4. del Castillo, FJ et al. (1997) The Escherichia coli K-12 sheA gene encodes a 34-kDa secreted haemolysin. Mol. Microbiol. 25 107-15 PubMed GONUTS page
  5. 5.0 5.1 Ludwig, A et al. (1999) Analysis of the SlyA-controlled expression, subcellular localization and pore-forming activity of a 34 kDa haemolysin (ClyA) from Escherichia coli K-12. Mol. Microbiol. 31 557-67 PubMed GONUTS page