PMID:10587333

Citation	del MonteF, , Harding, SE, Schmidt, U, Matsui, T, Kang, ZB, Dec, GW, Gwathmey, JK, Rosenzweig, A and Hajjar, RJ (1999) Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a. Circulation 100:2308-11
Abstract	Failing human myocardium is characterized by abnormal relaxation, a deficient sarcoplasmic reticulum (SR) Ca(2+) uptake, and a negative frequency response, which have all been related to a deficiency in the SR Ca(2+) ATPase (SERCA2a) pump.
Links	PubMed PMC1249502
Keywords	Calcium/metabolism; Calcium-Transporting ATPases/analysis; Calcium-Transporting ATPases/genetics; Calcium-Transporting ATPases/metabolism; Cardiomyopathy, Dilated/physiopathology; Cardiomyopathy, Dilated/therapy; Cells, Cultured; Gene Expression; Genetic Therapy; Heart Failure/physiopathology; Heart Failure/therapy; Humans; Muscle Fibers, Skeletal/cytology; Muscle Fibers, Skeletal/enzymology; Myocardial Contraction/genetics; Sarcoplasmic Reticulum/enzymology
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:AT2A2	involved_in	GO:0032469: endoplasmic reticulum calcium ion homeostasis	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:AT2A2	involved_in	GO:0006874: cellular calcium ion homeostasis	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:AT2A2	involved_in	GO:0010882: regulation of cardiac muscle contraction by calcium ion signaling	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:AT2A2	involved_in	GO:0055119: relaxation of cardiac muscle	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete

References

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