HUMAN:AT2A2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ATP2A2 (synonyms: ATP2B)
Protein Name(s)	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 SERCA2 SR Ca(2+)-ATPase 2 Calcium pump 2 Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform Endoplasmic reticulum class 1/2 Ca(2+) ATPase
External Links
UniProt	P16615
EMBL	M23114 M23116 M23115 M23278 M23116 AC006088 BC035588 AK293877 AY186578
CCDS	CCDS9143.1 CCDS9144.1
PIR	A31981 B31981
RefSeq	NP_001672.1 NP_733765.1 XP_005253945.1
UniGene	Hs.506759
ProteinModelPortal	P16615
SMR	P16615
BioGrid	106978
IntAct	P16615
MINT	MINT-4991144
STRING	9606.ENSP00000324892
ChEMBL	CHEMBL3901
TCDB	3.A.3.2.7
PhosphoSite	P16615
DMDM	114312
MaxQB	P16615
PaxDb	P16615
PRIDE	P16615
Ensembl	ENST00000308664 ENST00000539276 ENST00000553144
GeneID	488
KEGG	hsa:488
UCSC	uc001tqk.4 uc001tql.4
CTD	488
GeneCards	GC12P110719
HGNC	HGNC:812
HPA	HPA062605
MIM	101900 108740 124200
neXtProt	NX_P16615
Orphanet	79151 218
PharmGKB	PA71
eggNOG	COG0474
GeneTree	ENSGT00760000119003
HOGENOM	HOG000265621
HOVERGEN	HBG105648
InParanoid	P16615
KO	K05853
OMA	PKESRDN
OrthoDB	EOG73Z2SF
PhylomeDB	P16615
TreeFam	TF300651
Reactome	REACT_118798 REACT_23765 REACT_25149
SignaLink	P16615
ChiTaRS	ATP2A2
GenomeRNAi	488
NextBio	2031
PRO	PR:P16615
Proteomes	UP000005640
Bgee	P16615
CleanEx	HS_ATP2A2
ExpressionAtlas	P16615
Genevestigator	P16615
GO	GO:0090534 GO:0005783 GO:0005789 GO:0005887 GO:0014801 GO:0016020 GO:0031095 GO:0016529 GO:0033017 GO:0005524 GO:0005509 GO:0005388 GO:0086039 GO:0019899 GO:0046872 GO:0008022 GO:0044548 GO:0007596 GO:1990036 GO:0070588 GO:1903515 GO:0007155 GO:0006874 GO:0032469 GO:0008544 GO:0006984 GO:0034220 GO:0045822 GO:0032470 GO:0010460 GO:0098909 GO:0086036 GO:0010882 GO:0002026 GO:0055119 GO:0070296 GO:0055085
Gene3D	1.20.1110.10 2.70.150.10 3.40.1110.10
InterPro	IPR006068 IPR004014 IPR023299 IPR018303 IPR023298 IPR008250 IPR023214 IPR005782 IPR001757 IPR030327
PANTHER	PTHR24093:SF234
Pfam	PF00689 PF00690 PF00122 PF00702
PRINTS	PR00119 PR00120
SMART	SM00831
SUPFAM	SSF56784 SSF81660
TIGRFAMs	TIGR01116 TIGR01494
PROSITE	PS00154

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0005509	calcium ion binding	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1990036	calcium ion import into sarcoplasmic reticulum	PMID:16402920^[1]	ECO:0000305	curator inference used in manual assertion	GO:1903515	P		Seeded From UniProt	complete
involved_in	GO:0032470	positive regulation of endoplasmic reticulum calcium ion concentration	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11507-1	P		Seeded From UniProt	complete
involved_in	GO:0086036	regulation of cardiac muscle cell membrane potential	PMID:16402920^[1]	ECO:0000305	curator inference used in manual assertion	GO:0005388 GO:1903515	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:16081076^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0086039	calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11507	F	occurs_at:(GO:0033017)	Seeded From UniProt	complete
involved_in	GO:1990036	calcium ion import into sarcoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11507	P	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
involved_in	GO:0098909	regulation of cardiac muscle cell action potential involved in regulation of contraction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11507	P		Seeded From UniProt	complete
involved_in	GO:0086036	regulation of cardiac muscle cell membrane potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11507	P		Seeded From UniProt	complete
enables	GO:0086039	calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential	PMID:16402920^[1]	ECO:0000305	curator inference used in manual assertion	GO:0005388 GO:1903515	F		Seeded From UniProt	complete
enables	GO:0005388	calcium-transporting ATPase activity	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1903515	calcium ion transport from cytosol to endoplasmic reticulum	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032469	endoplasmic reticulum calcium ion homeostasis	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:21903937^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q08499	F	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
enables	GO:0044548	S100 protein binding	PMID:12804600^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P23297	F		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	PMID:12804600^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:11402072^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0086039	calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000643405 RGD:2174	F		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000643382 RGD:2174 UniProtKB:P16615	P		Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105058 PANTHER:PTN000643383	C		Seeded From UniProt	complete
involved_in	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000643405 RGD:2174 UniProtKB:P16615	P		Seeded From UniProt	complete
enables	GO:0008553	proton-exporting ATPase activity, phosphorylative mechanism	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001943383 PomBase:SPAC1071.10c PomBase:SPCC1020.01c SGD:S000002976 SGD:S000005957 TAIR:locus:2020372 TAIR:locus:2044450 TAIR:locus:2165600 UniProtKB:A0A1D8PJ01	F		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0263006 MGI:MGI:88110 PANTHER:PTN000643382 UniProtKB:P16615 WB:WBGene00004736 ZFIN:ZDB-GENE-020905-1	P		Seeded From UniProt	complete
enables	GO:0005388	calcium-transporting ATPase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88110 PANTHER:PTN000643382 RGD:2174 RGD:621293 TAIR:locus:2201916 UniProtKB:O14983 UniProtKB:P16615 WB:WBGene00004736	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:22375059^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0099132	ATP hydrolysis coupled cation transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005388	P		Seeded From UniProt	complete
involved_in	GO:0099132	ATP hydrolysis coupled cation transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005388	P		Seeded From UniProt	complete
involved_in	GO:0099132	ATP hydrolysis coupled cation transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005388	P		Seeded From UniProt	complete
involved_in	GO:0099132	ATP hydrolysis coupled cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005388	P		Seeded From UniProt	complete
involved_in	GO:0099132	ATP hydrolysis coupled cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005388	P		Seeded From UniProt	complete
involved_in	GO:1902600	proton transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008553	P		Seeded From UniProt	complete
involved_in	GO:1903233	regulation of calcium ion-dependent exocytosis of neurotransmitter	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55143 ensembl:ENSMUSP00000031423	P		Seeded From UniProt	complete
part_of	GO:0097470	ribbon synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55143 ensembl:ENSMUSP00000031423	C		Seeded From UniProt	complete
involved_in	GO:0070296	sarcoplasmic reticulum calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55143 ensembl:ENSMUSP00000031423	P		Seeded From UniProt	complete
involved_in	GO:0045822	negative regulation of heart contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55143 ensembl:ENSMUSP00000031423	P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55143 ensembl:ENSMUSP00000031423	P		Seeded From UniProt	complete
involved_in	GO:0033292	T-tubule organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55143 ensembl:ENSMUSP00000031423	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55143 ensembl:ENSMUSP00000031423	F		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55143 ensembl:ENSMUSP00000031423	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55143 ensembl:ENSMUSP00000031423	C		Seeded From UniProt	complete
involved_in	GO:0014898	cardiac muscle hypertrophy in response to stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55143 ensembl:ENSMUSP00000031423	P		Seeded From UniProt	complete
involved_in	GO:0014883	transition between fast and slow fiber	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55143 ensembl:ENSMUSP00000031423	P		Seeded From UniProt	complete
involved_in	GO:0006996	organelle organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55143 ensembl:ENSMUSP00000031423	P		Seeded From UniProt	complete
involved_in	GO:0006984	ER-nucleus signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55143 ensembl:ENSMUSP00000031423	P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55143 ensembl:ENSMUSP00000031423	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55143 ensembl:ENSMUSP00000031423	C		Seeded From UniProt	complete
enables	GO:0005388	calcium-transporting ATPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55143 ensembl:ENSMUSP00000031423	F		Seeded From UniProt	complete
involved_in	GO:0002026	regulation of the force of heart contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55143 ensembl:ENSMUSP00000031423	P		Seeded From UniProt	complete
involved_in	GO:1990036	calcium ion import into sarcoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11507 ensembl:ENSRNOP00000024347	P		Seeded From UniProt	complete
part_of	GO:0120025	plasma membrane bounded cell projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11507 ensembl:ENSRNOP00000024347	C		Seeded From UniProt	complete
involved_in	GO:0098909	regulation of cardiac muscle cell action potential involved in regulation of contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11507 ensembl:ENSRNOP00000024347	P		Seeded From UniProt	complete
enables	GO:0086039	calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11507 ensembl:ENSRNOP00000024347	F		Seeded From UniProt	complete
involved_in	GO:0086036	regulation of cardiac muscle cell membrane potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11507 ensembl:ENSRNOP00000024347	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11507 ensembl:ENSRNOP00000024347	P		Seeded From UniProt	complete
involved_in	GO:0070296	sarcoplasmic reticulum calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11507 ensembl:ENSRNOP00000024347	P		Seeded From UniProt	complete
part_of	GO:0061831	apical ectoplasmic specialization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11507 ensembl:ENSRNOP00000024347	C		Seeded From UniProt	complete
involved_in	GO:0055119	relaxation of cardiac muscle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11507 ensembl:ENSRNOP00000024347	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11507 ensembl:ENSRNOP00000024347	C		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11507 ensembl:ENSRNOP00000024347	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11507 ensembl:ENSRNOP00000024347	C		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11507 ensembl:ENSRNOP00000024347	P		Seeded From UniProt	complete
enables	GO:0031775	lutropin-choriogonadotropic hormone receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11507 ensembl:ENSRNOP00000024347	F		Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11507 ensembl:ENSRNOP00000024347	C		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11507 ensembl:ENSRNOP00000024347	C		Seeded From UniProt	complete
part_of	GO:0012506	vesicle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11507 ensembl:ENSRNOP00000024347	C		Seeded From UniProt	complete
involved_in	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11507 ensembl:ENSRNOP00000024347	P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11507 ensembl:ENSRNOP00000024347	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11507 ensembl:ENSRNOP00000024347	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11507 ensembl:ENSRNOP00000024347	F		Seeded From UniProt	complete
enables	GO:0005388	calcium-transporting ATPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11507 ensembl:ENSRNOP00000024347	F		Seeded From UniProt	complete
involved_in	GO:0003009	skeletal muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11507 ensembl:ENSRNOP00000024347	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR023299	F		Seeded From UniProt	complete
enables	GO:0005388	calcium-transporting ATPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005782 InterPro:IPR030332	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030332	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030332	C		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005782	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001757 InterPro:IPR005782 InterPro:IPR030332	C		Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030332	C		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030332	P		Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	PMID:16402920^[1]	ECO:0000305	curator inference used in manual assertion	GO:0016529	C	part_of:(UBERON:0002084)	Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002084)	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032469	endoplasmic reticulum calcium ion homeostasis	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903515	calcium ion transport from cytosol to endoplasmic reticulum	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990036	calcium ion import into sarcoplasmic reticulum	PMID:16402920^[1]	ECO:0000305	curator inference used in manual assertion	GO:1903515	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_at:(GO:0005789)	Seeded From UniProt	complete
enables	GO:0005388	calcium-transporting ATPase activity	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(GO:0005783)	Seeded From UniProt	complete
part_of	GO:0090534	calcium ion-transporting ATPase complex	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(GO:0005783)	Seeded From UniProt	complete
involved_in	GO:0032470	positive regulation of endoplasmic reticulum calcium ion concentration	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0086039	calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential	PMID:16402920^[1]	ECO:0000305	curator inference used in manual assertion	GO:0005388 GO:1903515	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:14749390^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15035	F		Seeded From UniProt	complete
involved_in	GO:0086036	regulation of cardiac muscle cell membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0086039	P		Seeded From UniProt	complete
involved_in	GO:0099132	ATP hydrolysis coupled cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005388	P		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005388	calcium-transporting ATPase activity	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(GO:0005783)	Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_at:(GO:0005789)	Seeded From UniProt	complete
involved_in	GO:1990036	calcium ion import into sarcoplasmic reticulum	PMID:16402920^[1]	ECO:0000305	curator inference used in manual assertion	GO:1903515	P		Seeded From UniProt	complete
involved_in	GO:0032469	endoplasmic reticulum calcium ion homeostasis	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903515	calcium ion transport from cytosol to endoplasmic reticulum	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	PMID:16402920^[1]	ECO:0000305	curator inference used in manual assertion	GO:0014801	C	part_of:(UBERON:0002084)	Seeded From UniProt	complete
part_of	GO:0014801	longitudinal sarcoplasmic reticulum	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002084)	Seeded From UniProt	complete
part_of	GO:0090534	calcium ion-transporting ATPase complex	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(GO:0005783)	Seeded From UniProt	complete
involved_in	GO:0032470	positive regulation of endoplasmic reticulum calcium ion concentration	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0086039	calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential	PMID:16402920^[1]	ECO:0000305	curator inference used in manual assertion	GO:0005388 GO:1903515	F		Seeded From UniProt	complete
involved_in	GO:0032469	endoplasmic reticulum calcium ion homeostasis	PMID:10587333^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	PMID:10587333^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	PMID:10587333^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055119	relaxation of cardiac muscle	PMID:10587333^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0086036	regulation of cardiac muscle cell membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0086039	P		Seeded From UniProt	complete
involved_in	GO:0099132	ATP hydrolysis coupled cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005388	P		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005388	calcium-transporting ATPase activity	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(GO:0005783)	Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_at:(GO:0005789)	Seeded From UniProt	complete
involved_in	GO:1990036	calcium ion import into sarcoplasmic reticulum	PMID:16402920^[1]	ECO:0000305	curator inference used in manual assertion	GO:1903515	P		Seeded From UniProt	complete
involved_in	GO:0032469	endoplasmic reticulum calcium ion homeostasis	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903515	calcium ion transport from cytosol to endoplasmic reticulum	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	PMID:16402920^[1]	ECO:0000305	curator inference used in manual assertion	GO:0014801	C	part_of:(UBERON:0002084)	Seeded From UniProt	complete
part_of	GO:0014801	longitudinal sarcoplasmic reticulum	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002084)	Seeded From UniProt	complete
colocalizes_with	GO:0014704	intercalated disc	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002084)	Seeded From UniProt	complete
part_of	GO:0090534	calcium ion-transporting ATPase complex	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(GO:0005783)	Seeded From UniProt	complete
involved_in	GO:0032470	positive regulation of endoplasmic reticulum calcium ion concentration	PMID:16402920^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0086039	calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential	PMID:16402920^[1]	ECO:0000305	curator inference used in manual assertion	GO:0005388 GO:1903515	F		Seeded From UniProt	complete
involved_in	GO:0086036	regulation of cardiac muscle cell membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0086039	P		Seeded From UniProt	complete
involved_in	GO:0099132	ATP hydrolysis coupled cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005388	P		Seeded From UniProt	complete
involved_in	GO:0008544	epidermis development	PMID:10080178^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:10080178^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:2844796^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0086039	calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential	PMID:22679139^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0086036	regulation of cardiac muscle cell membrane potential	PMID:22679139^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070296	sarcoplasmic reticulum calcium ion transport	PMID:22679139^[12] PMID:19095005^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	PMID:19095005^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010460	positive regulation of heart rate	PMID:22679139^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903779	regulation of cardiac conduction	Reactome:R-HSA-5578775	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	Reactome:R-HSA-936837	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031095	platelet dense tubular network membrane	Reactome:R-HSA-418365	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-HSA-427910	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0109	P		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0703	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0241	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 ^1.21 ^1.22 ^1.23 ^1.24 ^1.25 ^1.26 ^1.27 ^1.28 ^1.29 ^1.30 ^1.31 ^1.32 ^1.33 ^1.34 ^1.35 ^1.36 ^1.37 ^1.38 ^1.39 ^1.40 ^1.41 ^1.42 Dally, S et al. (2006) Ca2+-ATPases in non-failing and failing heart: evidence for a novel cardiac sarco/endoplasmic reticulum Ca2+-ATPase 2 isoform (SERCA2c). Biochem. J. 395 249-58 PubMed GONUTS page
↑ Suga, K et al. (2005) RNA interference-mediated silencing of the syntaxin 5 gene induces Golgi fragmentation but capable of transporting vesicles. FEBS Lett. 579 4226-34 PubMed GONUTS page
↑ Beca, S et al. (2011) Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current. Circ. Res. 109 1024-30 PubMed GONUTS page
↑ ^4.0 ^4.1 Kiewitz, R et al. (2003) Ca2+ -dependent interaction of S100A1 with the sarcoplasmic reticulum Ca2+ -ATPase2a and phospholamban in the human heart. Biochem. Biophys. Res. Commun. 306 550-7 PubMed GONUTS page
↑ Chami, M et al. (2001) SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis. J. Cell Biol. 153 1301-14 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Lang, S et al. (2012) Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. J. Cell. Sci. 125 1958-69 PubMed GONUTS page
↑ Stefanovic, B et al. (2004) TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Mol. Cell. Biol. 24 1758-68 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 del MonteF, et al. (1999) Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a. Circulation 100 2308-11 PubMed GONUTS page
↑ ^10.0 ^10.1 Sakuntabhai, A et al. (1999) Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nat. Genet. 21 271-7 PubMed GONUTS page
↑ Lytton, J & MacLennan, DH (1988) Molecular cloning of cDNAs from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase gene. J. Biol. Chem. 263 15024-31 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Kranias, EG & Hajjar, RJ (2012) Modulation of cardiac contractility by the phospholamban/SERCA2a regulatome. Circ. Res. 110 1646-60 PubMed GONUTS page
↑ ^13.0 ^13.1 Yamazaki, D et al. (2009) New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes. Pharmacol. Ther. 121 265-72 PubMed GONUTS page

[PMID:16402920-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 ^1.21 ^1.22 ^1.23 ^1.24 ^1.25 ^1.26 ^1.27 ^1.28 ^1.29 ^1.30 ^1.31 ^1.32 ^1.33 ^1.34 ^1.35 ^1.36 ^1.37 ^1.38 ^1.39 ^1.40 ^1.41 ^1.42 Dally, S et al. (2006) Ca2+-ATPases in non-failing and failing heart: evidence for a novel cardiac sarco/endoplasmic reticulum Ca2+-ATPase 2 isoform (SERCA2c). Biochem. J. 395 249-58 PubMed GONUTS page

[PMID:16081076-2] Suga, K et al. (2005) RNA interference-mediated silencing of the syntaxin 5 gene induces Golgi fragmentation but capable of transporting vesicles. FEBS Lett. 579 4226-34 PubMed GONUTS page

[PMID:21903937-3] Beca, S et al. (2011) Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current. Circ. Res. 109 1024-30 PubMed GONUTS page

[PMID:12804600-4] 4.0 ^4.1 Kiewitz, R et al. (2003) Ca2+ -dependent interaction of S100A1 with the sarcoplasmic reticulum Ca2+ -ATPase2a and phospholamban in the human heart. Biochem. Biophys. Res. Commun. 306 550-7 PubMed GONUTS page

[PMID:11402072-5] Chami, M et al. (2001) SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis. J. Cell Biol. 153 1301-14 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22375059-7] Lang, S et al. (2012) Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. J. Cell. Sci. 125 1958-69 PubMed GONUTS page

[PMID:14749390-8] Stefanovic, B et al. (2004) TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Mol. Cell. Biol. 24 1758-68 PubMed GONUTS page

[PMID:10587333-9] 9.0 ^9.1 ^9.2 ^9.3 del MonteF, et al. (1999) Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a. Circulation 100 2308-11 PubMed GONUTS page

[PMID:10080178-10] 10.0 ^10.1 Sakuntabhai, A et al. (1999) Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nat. Genet. 21 271-7 PubMed GONUTS page

[PMID:2844796-11] Lytton, J & MacLennan, DH (1988) Molecular cloning of cDNAs from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase gene. J. Biol. Chem. 263 15024-31 PubMed GONUTS page

[PMID:22679139-12] 12.0 ^12.1 ^12.2 ^12.3 Kranias, EG & Hajjar, RJ (2012) Modulation of cardiac contractility by the phospholamban/SERCA2a regulatome. Circ. Res. 110 1646-60 PubMed GONUTS page

[PMID:19095005-13] 13.0 ^13.1 Yamazaki, D et al. (2009) New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes. Pharmacol. Ther. 121 265-72 PubMed GONUTS page

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HUMAN:AT2A2

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