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PLAF7:Q8I3W6

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Species (Taxon ID) Plasmodium falciparum (isolate 3D7). (36329)
Gene Name(s) No Information Provided.
Protein Name(s) Helicase, belonging to UvrD family, putative (ECO:0000313 with EMBL:CAD51506.1)
External Links
UniProt Q8I3W6
EMBL AL844504
RefSeq XP_001351699.1
ProteinModelPortal Q8I3W6
SMR Q8I3W6
STRING 5833.PFE0705c-1
EnsemblProtists PFE0705c:mRNA
GeneID 812956
KEGG pfa:PFE0705c
EuPathDB PlasmoDB:PF3D7_0514100
HOGENOM HOG000212539
InParanoid Q8I3W6
Proteomes UP000001450
GO GO:0005634
GO:0005524
GO:0043140
GO:0003677
GO:0043142
GO:0006200
GO:0032508
Gene3D 3.40.50.300
InterPro IPR014017
IPR000212
IPR027417
IPR014016
PANTHER PTHR11070
Pfam PF00580
PF13361
SUPFAM SSF52540
PROSITE PS51198
PS51217

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0043138

3'-5' DNA helicase activity

PMID:23185322[1]

ECO:0000314

F

Figure 8 shows the ability of the protein to unwind dsDNA in the 3' to 5' direction.

complete
CACAO 6629

NOT

GO:0043139

5'-3' DNA helicase activity

PMID:23185322[1]

ECO:0000314

F

Figure 8 shows the inability of PfUDN to unwind dsDNA in the 5' to 3' direction.

complete
CACAO 6630

NOT|enables

GO:0043139

5'-3' DNA helicase activity

PMID:23185322[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0043138

3'-5' DNA helicase activity

PMID:23185322[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0043140

ATP-dependent 3'-5' DNA helicase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10426
PANTHER:PTN000116141
SGD:S000005455
UniProtKB:A0A1D8PUB1
UniProtKB:P9WMQ1
UniProtKB:Q8I3W6

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11064
PANTHER:PTN000116141
PomBase:SPAC4H3.05
PomBase:SPBC336.01
SGD:S000003628
UniProtKB:F1ND48
UniProtKB:G3XD04
UniProtKB:P9WMQ1

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000116143
PomBase:SPBC336.01
SGD:S000003628
UniProtKB:Q8I3W6
UniProtKB:Q8NFZ0

C

Seeded From UniProt

complete

involved_in

GO:0000725

recombinational repair

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000116141
PomBase:SPAC4H3.05
PomBase:SPBC336.01
UniProtKB:F1ND48

P

Seeded From UniProt

complete

enables

GO:0043142

single-stranded DNA-dependent ATPase activity

PMID:23185322[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0043140

ATP-dependent 3'-5' DNA helicase activity

PMID:23185322[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:23185322[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0032508

DNA duplex unwinding

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004003

P

Seeded From UniProt

complete

involved_in

GO:0032508

DNA duplex unwinding

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0043139

P

Seeded From UniProt

complete

involved_in

GO:0032508

DNA duplex unwinding

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0043138

P

Seeded From UniProt

complete

involved_in

GO:0032508

DNA duplex unwinding

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0043140

P

Seeded From UniProt

complete

involved_in

GO:0032508

DNA duplex unwinding

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0043140

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000212

F

Seeded From UniProt

complete

enables

GO:0004003

ATP-dependent DNA helicase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000212

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000212
InterPro:IPR014016
InterPro:IPR014017
InterPro:IPR034739

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR014017

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0004386

helicase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0347

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Ahmad, M et al. (2012) Plasmodium falciparum UvrD helicase translocates in 3' to 5' direction, colocalizes with MLH and modulates its activity through physical interaction. PLoS ONE 7 e49385 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page