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PIG:MDHC
Contents
Species (Taxon ID) | Sus scrofa (Pig). (9823) | |
Gene Name(s) | MDH1 | |
Protein Name(s) | Malate dehydrogenase, cytoplasmic
Cytosolic malate dehydrogenase | |
External Links | ||
UniProt | P11708 | |
EMBL | U44846 M29463 | |
PIR | JC4876 | |
RefSeq | NP_999039.1 | |
UniGene | Ssc.11103 | |
PDB | 4MDH 5MDH | |
PDBsum | 4MDH 5MDH | |
ProteinModelPortal | P11708 | |
SMR | P11708 | |
BindingDB | P11708 | |
ChEMBL | CHEMBL4048 | |
PRIDE | P11708 | |
GeneID | 396894 | |
KEGG | ssc:396894 | |
CTD | 4190 | |
HOVERGEN | HBG006340 | |
InParanoid | P11708 | |
KO | K00025 | |
BioCyc | MetaCyc:MONOMER-13033 | |
SABIO-RK | P11708 | |
EvolutionaryTrace | P11708 | |
Proteomes | UP000008227 | |
GO | GO:0005829 GO:0030060 GO:0044262 GO:0006108 GO:0006099 | |
Gene3D | 3.40.50.720 3.90.110.10 | |
HAMAP | MF_01517 | |
InterPro | IPR001557 IPR022383 IPR001236 IPR015955 IPR001252 IPR011274 IPR010945 IPR016040 | |
PANTHER | PTHR23382 | |
Pfam | PF02866 PF00056 | |
PIRSF | PIRSF000102 | |
SUPFAM | SSF56327 | |
TIGRFAMs | TIGR01759 TIGR01758 | |
PROSITE | PS00068 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
enables |
GO:0051287 |
NAD binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0030060 |
L-malate dehydrogenase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0262782 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006734 |
NADH metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000600336 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006108 |
malate metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000600336 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006107 |
oxaloacetate metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000600336 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006099 |
tricarboxylic acid cycle |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000600336 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0262782 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0005975 |
carbohydrate metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006108 |
malate metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016615 |
malate dehydrogenase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016616 |
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0019752 |
carboxylic acid metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0030060 |
L-malate dehydrogenase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001236 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0030060 |
L-malate dehydrogenase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006099 |
tricarboxylic acid cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Chapman, AD et al. (1999) Structural basis of substrate specificity in malate dehydrogenases: crystal structure of a ternary complex of porcine cytoplasmic malate dehydrogenase, alpha-ketomalonate and tetrahydoNAD. J. Mol. Biol. 285 703-12 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Joh, T et al. (1987) Cloning and sequence analysis of cDNAs encoding mammalian cytosolic malate dehydrogenase. Comparison of the amino acid sequences of mammalian and bacterial malate dehydrogenase. J. Biol. Chem. 262 15127-31 PubMed GONUTS page
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