PIG:LEP

Species (Taxon ID)	Sus scrofa (Pig). (9823)
Gene Name(s)	LEP (synonyms: OB, OBS)
Protein Name(s)	Leptin Obesity factor
External Links
UniProt	Q29406
EMBL	U63540 AF026976 U66254 U59894 AF052691 AF102856 AF477387 AF477386 U40812
RefSeq	NP_999005.1
UniGene	Ssc.102384 Ssc.265
ProteinModelPortal	Q29406
SMR	Q29406
STRING	9823.ENSSSCP00000017572
PaxDb	Q29406
PRIDE	Q29406
GeneID	396832
KEGG	ssc:396832
CTD	3952
eggNOG	ENOG410IVT0 ENOG410Y7NT
HOGENOM	HOG000252923
HOVERGEN	HBG007860
InParanoid	Q29406
KO	K05424
OMA	QISNDLE
OrthoDB	EOG091G0Y82
TreeFam	TF105086
Proteomes	UP000008227
GO	GO:0005615 GO:0005622 GO:0005179 GO:0051428 GO:1990051 GO:0098868 GO:0044320 GO:0006112 GO:0032615 GO:0032635 GO:0072604 GO:0072606 GO:0050892 GO:0033210 GO:0006629 GO:0038108 GO:0010507 GO:0046325 GO:0006909 GO:0046427 GO:0043410 GO:1900745 GO:0014068 GO:0051897 GO:0042102 GO:0032008 GO:0032760 GO:0032310 GO:0045765 GO:0046850 GO:0090335 GO:0051726 GO:1900015 GO:0001936 GO:0032814 GO:0042269 GO:0032817 GO:0050999 GO:0032868 GO:0019953 GO:0030217 GO:0007260
InterPro	IPR009079 IPR000065
PANTHER	PTHR11724
Pfam	PF02024
PIRSF	PIRSF001837
PRINTS	PR00495
ProDom	PD005698
SUPFAM	SSF47266

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:1900534	palmitic acid catabolic process	PMID:14677856^[1]	ECO:0000314			P	Figure 4 shows that in pigs chronic exposure to porcine leptin increases the relative rate of palmitate oxidation. Submitting new go term request for 'Positive regulation of palmitic acid catabolic process'	complete CACAO 13427
	GO:0046627	glucose catabolic process	PMID:14677856^[1]	ECO:0000314			P	Figure 1 shows that acute treatment with porcine leptin reduced the rate of glucose oxidation in pig adipocyte cultures.	complete CACAO 13431
	GO:0006007	glucose catabolic process	PMID:14677856^[1]	ECO:0000314			P	Figure 2 shows that chronic treatment with porcine leptin reduced the rate of glucose oxidation in pig adipocyte containing cultures	complete CACAO 13436
	GO:0051055	negative regulation of lipid biosynthetic process	PMID:14677856^[1]	ECO:0000314			P	Figure 6 shows that chronic leptin treatment reduce the total glucose incorporation into lipids(lipid biosynthesis) vs controls in pig adipocyte containing cultures.	complete CACAO 13437
	GO:1900533	palmitic acid metabolic process	PMID:14677856^[1]	ECO:0000314			P	Figure 7 shows that acute treatment with porcine leptin caused a decrease in palmitate esterification in pig adipocyte-containing primary cultures.	complete CACAO 13438
	GO:0045717	negative regulation of fatty acid biosynthetic process	PMID:14677856^[1]	ECO:0000314			P	Figure 10 shows that chronic treatment with porcine leptin decreased fatty acid synthesis in a dose dependent manner in pig adipocyte containing primary cultures	complete CACAO 13439
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:0032635	interleukin-6 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:0032615	interleukin-12 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:0030217	T cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:0098868	bone growth	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:0050999	regulation of nitric-oxide synthase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0046850	regulation of bone remodeling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:1900015	regulation of cytokine production involved in inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0072606	interleukin-8 secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0072604	interleukin-6 secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0032310	prostaglandin secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0045765	regulation of angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0001936	regulation of endothelial cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:1990051	activation of protein kinase C activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:1900745	positive regulation of p38MAPK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0050892	intestinal absorption	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0046325	negative regulation of glucose import	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:0019953	sexual reproduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:0038108	negative regulation of appetite by leptin-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P50596	P	Seeded From UniProt	complete
involved_in	GO:0042269	regulation of natural killer cell mediated cytotoxicity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0032817	regulation of natural killer cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0032814	regulation of natural killer cell activation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0044320	cellular response to leptin stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0090335	regulation of brown fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:0032008	positive regulation of TOR signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G8BLB4	P	Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P50595	P	Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P50596	P	Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P50596	P	Seeded From UniProt	complete
involved_in	GO:1990051	activation of protein kinase C activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001711963 UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:1900745	positive regulation of p38MAPK cascade	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001711963 UniProtKB:P41159	P	Seeded From UniProt	complete
enables	GO:0051428	peptide hormone receptor binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001711963 RGD:3000	F	Seeded From UniProt	complete
involved_in	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104663 PANTHER:PTN001711963 RGD:3000 UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0038108	negative regulation of appetite by leptin-mediated signaling pathway	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001711963 RGD:3000	P	Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104663 PANTHER:PTN001711963 UniProtKB:G8BLB4 UniProtKB:P50595	P	Seeded From UniProt	complete
involved_in	GO:0032008	positive regulation of TOR signaling	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001711963 UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104663 PANTHER:PTN001711963 RGD:3000 UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0007260	tyrosine phosphorylation of STAT protein	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104663 PANTHER:PTN001711963	P	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104663 PANTHER:PTN001711963	P	Seeded From UniProt	complete
involved_in	GO:0006112	energy reserve metabolic process	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001711963 RGD:3000	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104663 PANTHER:PTN001711963 RGD:3000 UniProtKB:G8BLB4 UniProtKB:O42164 UniProtKB:P50595	C	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001711963 RGD:3000	F	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000065	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000065	C	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000065	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Ramsay, TG (2003) Porcine leptin inhibits lipogenesis in porcine adipocytes. J. Anim. Sci. 81 3008-17 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:14677856-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Ramsay, TG (2003) Porcine leptin inhibits lipogenesis in porcine adipocytes. J. Anim. Sci. 81 3008-17 PubMed GONUTS page

[PMID:21873635-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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PIG:LEP

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