PIG:IL6

Species (Taxon ID)	Sus scrofa (Pig). (9823)
Gene Name(s)	IL6
Protein Name(s)	Interleukin-6 IL-6
External Links
UniProt	P26893
EMBL	M86722 M80258 AF309651
PIR	I46590 I46621
RefSeq	NP_001239358.1 NP_999564.1
UniGene	Ssc.62
ProteinModelPortal	P26893
SMR	P26893
STRING	9823.ENSSSCP00000016312
GeneID	100628202 399500
KEGG	ssc:100628202 ssc:399500
CTD	100136689 3569
eggNOG	NOG48083
HOGENOM	HOG000236330
HOVERGEN	HBG000471
InParanoid	P26893
KO	K05405
Proteomes	UP000008227
GO	GO:0005615 GO:0006953 GO:0072540
Gene3D	1.20.1250.10
InterPro	IPR009079 IPR012351 IPR003574 IPR003573
PANTHER	PTHR11457
Pfam	PF00489
PIRSF	PIRSF001935
PRINTS	PR00433 PR00434
SMART	SM00126
SUPFAM	SSF47266
PROSITE	PS00254

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:2000866	positive regulation of estradiol secretion	PMID:24139936	ECO:0000314			P		Day 15 and 16 of Pregnancy figure 4 show that increased IL-6 leads to increased estradiol 17beta secretion.	complete CACAO 8995
involved_in	GO:2000866	positive regulation of estradiol secretion	PMID:24139936	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072540	T-helper 17 cell lineage commitment	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08505	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030474	F		Seeded From UniProt	complete
enables	GO:0005138	interleukin-6 receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003574	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003574 InterPro:IPR030474	C		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003574 InterPro:IPR030474	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
involved_in	GO:0006953	acute-phase response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0011	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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References

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