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PIG:IL1B
Contents
| Species (Taxon ID) | Sus scrofa (Pig). (9823) | |
| Gene Name(s) | IL1B | |
| Protein Name(s) | Interleukin-1 beta
IL-1 beta | |
| External Links | ||
| UniProt | P26889 | |
| EMBL | M86725 | |
| PIR | JN0724 | |
| RefSeq | NP_999220.1 | |
| UniGene | Ssc.28829 | |
| ProteinModelPortal | P26889 | |
| SMR | P26889 | |
| STRING | 9823.ENSSSCP00000008636 | |
| Ensembl | ENSSSCT00000008861 | |
| GeneID | 397122 | |
| KEGG | ssc:397122 | |
| CTD | 397122 | |
| eggNOG | NOG40099 | |
| GeneTree | ENSGT00510000048687 | |
| HOGENOM | HOG000246399 | |
| HOVERGEN | HBG007328 | |
| InParanoid | P26889 | |
| KO | K04519 | |
| OMA | SNDKIPV | |
| OrthoDB | EOG71P2BQ | |
| TreeFam | TF300203 | |
| Reactome | REACT_222868 REACT_248002 | |
| Proteomes | UP000008227 | |
| GO | GO:0005615 GO:0001660 GO:0006955 GO:0051781 | |
| InterPro | IPR008996 IPR003294 IPR003296 IPR020877 IPR000975 IPR028142 IPR003502 | |
| PANTHER | PTHR10078:SF20 | |
| Pfam | PF00340 PF02394 | |
| PRINTS | PR00262 PR00264 PR01357 | |
| SUPFAM | SSF50353 | |
| PROSITE | PS00253 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:2000866 |
positive regulation of estradiol secretion |
ECO:0000314 |
P |
Day 15 and 16 of Figure 4 show that increased IL-1beta resulted in an increase in estradiol 17 beta |
complete | |||||
|
enables |
GO:0005178 |
integrin binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000866 |
positive regulation of estradiol secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000556 |
positive regulation of T-helper 1 cell cytokine production |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032729 |
positive regulation of interferon-gamma production |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071222 |
cellular response to lipopolysaccharide |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000008572 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050999 |
regulation of nitric-oxide synthase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96543 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046330 |
positive regulation of JNK cascade |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96543 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96543 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045766 |
positive regulation of angiogenesis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96543 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96543 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032755 |
positive regulation of interleukin-6 production |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1859324 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030593 |
neutrophil chemotaxis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96543 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030141 |
secretory granule |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96543 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000008572 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96543 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010575 |
positive regulation of vascular endothelial growth factor production |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96543 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1859324 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005149 |
interleukin-1 receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000008572 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1859324 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005149 |
interleukin-1 receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006955 |
immune response |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051781 |
positive regulation of cell division |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001660 |
fever generation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005776 |
autophagosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Franczak, A et al. (2014) The effect of interleukin-1β, interleukin-6, and tumor necrosis factor-α on estradiol-17β release in the myometrium: the in vitro study on the pig model. Theriogenology 81 266-74 PubMed GONUTS page
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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- GO:2000866 ! positive regulation of estradiol secretion
- GO:0045766 ! positive regulation of angiogenesis
- GO:0032729 ! positive regulation of type II interferon production
- GO:0010575 ! positive regulation of vascular endothelial growth factor production
- GO:0010628 ! positive regulation of gene expression
- GO:0032755 ! positive regulation of interleukin-6 production
- GO:0043123 ! positive regulation of canonical NF-kappaB signal transduction
- GO:2000556 ! positive regulation of T-helper 1 cell cytokine production
- GO:0051781 ! positive regulation of cell division
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0046330 ! positive regulation of JNK cascade
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