PEPDI:UTXA

Species (Taxon ID)	Peptoclostridium difficile (Clostridium difficile). (1496)
Gene Name(s)	utxA (synonyms: tcdE)
Protein Name(s)	Protein UtxA
External Links
UniProt	P16153
EMBL	X60984 X60984 M30308 M30308 X92982 X51797
PIR	B37052
ProteinModelPortal	P16153
STRING	272563.CD0661
TCDB	1.E.19.3.1
eggNOG	ENOG4105QHJ ENOG4111YWV
InterPro	IPR006480
Pfam	PF05105
TIGRFAMs	TIGR01593

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0034291	canonical holin activity	PMID:22685398	ECO:0000314			F		Figure 8A-B. All three potential forms of TcdE (tcdEM1) or only M25 and M27 (tcdEM25) or only M27 (tcdEM27) were used. When expressed in E. coli, the TcdEM1 (pCD311) and TcdEM25 (pCD302) forms induced complete bacterial lysis within five minutes after thermo-induction whereas expression of the TcdEM27 form (pCD322) caused complete lysis only at about 40 min. As was the case for λS protein, lysis induced by expression of any of the putative forms of TcdE required expression of the λ endolysin. However, when expressed in E. coli λCmrΔ(SR), carrying a deletion in holin and endolysin genes, the λS, TcdEM1, TcdME25 and TcdEM27 forms did not cause lysis, indicating that the lysis in E. coli could not be due to over-expression of the λS and TcdE forms.	complete CACAO 12124
	GO:1901998	toxin transport	PMID:22685398	ECO:0000315			P		Figure 3A and 3B. In Fig 3A, there was a large reduction in the amount of toxin secreted by the mutant when compared to the wild-type strain. In Fig 3B, there is more toxin accumulated in the cytoplasm of the tcdE mutant than in the wild-type strain in stationary phase cells.	complete CACAO 12125
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References

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